Brain cyclooxygenase-mediated mechanisms in stress response

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790745
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Kochi University
• Principal Investigator: TANAKA Kenjiro 高知大学, 教育研究部医療学系, 助教 (30552260)
• Project Period (FY): 2011 – 2012
• Keywords: ストレス科学

Research Abstract

We demonstrated that pre-sympathetic neurons containing cyclooxygenase, a rate-limiting enzyme for the synthesis of prostanoids, in the hypothalamic paraventricular nucleus were involved in the activation of the sympatho-adrenomedullary outflow in rats. The present study also showed the possibility that the S-nitrosylation of brain cyclooxygenase is involved in the central activation of the sympatho-adrenomedullary outflow.

Research Products

• [Journal Article] Stimulatory and inhibitory roles of brain 2-arachidonoylglycerol in bombesin-induced central activation of adrenomedullary outflow in rats (2013)
  • Author(s): Shimizu T, Tanaka K, Yokotani K
  • Journal Title: J Pharmacol Sci Volume: 121 Pages: 157-171
  • DOI: DOI:10.1254/jphs.12208FP
  • Peer Reviewed
• [Journal Article] diacylglycerol lipase and monoacylglycerol lipase are involved in (±)-epibatidine-induced activation of central adrenomedullary outflow in rats (2012)
  • Author(s): Shimizu T, Tanaka K, Nakamura K, Taniuchi K, Yokotani K. Brain phospholipase C
  • Journal Title: Eur J Pharmacol Volume: 691 Pages: 93-102
  • DOI: DOI:10.1016/j.ejphar.2012.07.017
  • Peer Reviewed
• [Journal Article] Centrally administered bombesin activates COX-containing spinally projecting neurons of the PVN in anesthetized rats (2012)
  • Author(s): Tanaka K, Shimizu T, Lu L, Nakamura K, Yokotani K
  • Journal Title: Auton Neurosci Volume: 269 Pages: 63-69
  • DOI: DOI:10.1016/j.autneu.2012.03.006
  • Peer Reviewed
• [Journal Article] Possible involvement of S-nitrosylation of brain cyclooxygenase-1 in bombesin-induced central activation of adrenomedullary outflow in rats (2012)
  • Author(s): Tanaka K, Shimizu T, Lu L, Yokotani K
  • Journal Title: Eur J Pharmacol Volume: 679 Pages: 40-50
  • DOI: DOI:10.1016/j.ejphar.2012.01.005
  • Peer Reviewed
• [Presentation] Centrally administered bombesin induces S-nitrosylation of cyclooxygenase-1 in the spinally projecting neurons of the hypothalamic paraventricular nucleus in rats (2013)
  • Author(s): 田中健二朗ら
  • Organizer: 第86回 日本薬理学会年会
  • Place of Presentation: 福岡国際会議場(福岡)
  • Year and Date: 2013-03-23
• [Presentation] S-nitrosylation of cyclooxygenase in the hypothalamic paraventricular nucleus spinally projecting neurons is involved in bombesin-induced activation of central adrenomedullary outflow in rats (2012)
  • Author(s): 田中健二朗 ら
  • Organizer: 第85回 日本薬理学会年会
  • Place of Presentation: 京都国際会館(京都)
  • Year and Date: 2012-03-14
• [Presentation] Bombesin-induced activation of presympathetic and cyclooxygenase-containing neurons in the hypothalamic paraventricular nucleus (2011)
  • Author(s): 田中健二朗 ら
  • Organizer: 第34回 日本神経科学大会
  • Place of Presentation: パシフィコ横浜(神奈川)
  • Year and Date: 2011-09-15