2012 Fiscal Year Final Research Report
Therapeutic effect of natural compounds regulating macrophage activation on life style-diseases.
| Project/Area Number |
23790747
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General internal medicine (including Psychosomatic medicine)
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
FUJIWARA Yukio 熊本大学, 大学院・生命科学研究部, 助教 (70452886)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 代替医療 |
|---|
| Research Abstract |
It is well known that tumor-associated macrophages play an important role in cancer growth. In this study, we identified several natural compounds, such as corosolic acid and onionin which regulate macrophage activation. These compounds change M2 polarization to M1 polarization by inhibition of STAT3 activation in macrophages. Therefore, these compounds may be potentially new tool for tumor prevention and therapy.
|
