2012 Fiscal Year Final Research Report
Effects of Japanese herbal medicines on model mice of nonalcoholic steatohepatitis
| Project/Area Number |
23790753
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 東洋医学 |
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| Research Abstract |
In the present study, we examined the effects of Japanese herbal medicines on two kinds of model mice of NASH (methionine- and choline-deficient (MCD) diet-fed db/db mice and high-fat (HF) diet-fed db/db mice). As a result, sho-saiko-to (TJ-9) and juzen-taiho-to (TJ-48) significantly inhibited NASH in the MCD diet model, and inchin-ko-to (TJ-135) in addition to TJ-9 and TJ-48 significantly inhibited NASH in the HF diet model.
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