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2013 Fiscal Year Final Research Report

Search for infectious agents in pancreatitis by next-generation sequencing

Research Project

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Project/Area Number 23790764
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

KUME Kiyoshi  東北大学, 大学病院, 助教 (30431563)

Project Period (FY) 2011 – 2013
Keywords膵炎 / 感染症 / レクチン
Research Abstract

The vast majority of episodes of pancreatitis are noninfectious in origin, and the role of infectious agents in this disorder remains controversial. Next-generation sequencing has many potential applications in virology, such as discovery of new viruses, and detection of unexpected viral pathogens in clinical specimens. In this study, we could not discover of new viruses as the origin of pancreatitis. The major cause of death by acute pancreatitis is secondary infection of pancreatic tissue. Mannose-binding lectin (MBL) is one of the main components of immunity. We demonstrated that the prevalence of the codon 54 mutation of MBL gene in patients with infectious complications was slightly higher compared with patients without infectious complications (50% vs 27%).

  • Research Products

    (10 results)

All 2014 2013 2012 2011 2009

All Journal Article (7 results) (of which Peer Reviewed: 4 results) Presentation (3 results)

  • [Journal Article] PRSS1 c.623G>C (p.G208A) variant is associated with pancreatitis in Japan2014

    • Author(s)
      Masamune A, Nakano E, Kume K, Takikawa T, Kakuta Y, Shimosegawa T
    • Journal Title

      Gut

      Volume: 63 Pages: 366

    • Peer Reviewed
  • [Journal Article] Variants in CPA1 are strongly associated with early onset chronic pancreatitis2013

    • Author(s)
      Witt H, Beer S, Rosendahl J, Chen JM, Chandak GR, Masamune A, Bence M, Szmola R, Oracz G, Macek M Jr, Bhatia E, Steigenberger S, Lasher D, Bühler F, Delaporte C, Tebbing J, Ludwig M, Pilsak C, Saum K, Bugert P, Masson E, Paliwal S, Bhaskar S, Sobczynska-Tomaszewska A, Bak D, Balascak I, Choudhuri G, Nageshwar Reddy D, Rao GV, Thomas V, Kume K, Nakano E, Kakuta Y, Shimosegawa T, Durko L, Szabó A, Schnúr A, Hegyi P, Rakonczay Z Jr, Pfützer R, Schneider A, Groneberg DA, Braun M, Schmidt H, Witt U, Friess H, Algül H, Landt O, Schuelke M, Krüger R, Wiedenmann B, Schmidt F, Zimmer KP, Kovacs P, Stumvoll M, Blüher M, Müller T, Janecke A, Teich N, Grützmann R, Schulz HU, Mössner J, Keim V, Löhr M, Férec C, Sahin-Tóth M.
    • Journal Title

      Nat Genet

      Volume: 45 Pages: 1216-1220

    • Peer Reviewed
  • [Journal Article] Identification of novel missense CTRC variants in Japanese patients with chronic pancreatitis2013

    • Author(s)
      Masamune A, Nakano E, Kume K, Kakuta Y, Ariga H, Shimosegawa T
    • Journal Title

      Gut

      Volume: 62 Pages: 653-654

    • Peer Reviewed
  • [Journal Article] Do genetic variants in the SPINK1 gene affect the level of serum PSTI?2012

    • Author(s)
      Kume K, Masamune A, Ariga H, Hayashi S, Takikawa T, Miura S, Suzuki N, Kikuta K, Hamada S, Hirota M, Kanno A, Shimosegawa T
    • Journal Title

      J Gastroenterol

      Volume: 47 Pages: 1267-1274

    • Peer Reviewed
  • [Journal Article] 遺伝子解析の進展新しい変異は日本で意味があるのか?2012

    • Author(s)
      粂潔、下瀬川徹
    • Journal Title

      肝・胆・膵

      Volume: 64 Pages: 913-917

  • [Journal Article] 遺伝子多型は膵炎発症にどのように関与するか2011

    • Author(s)
      粂潔、下瀬川徹
    • Journal Title

      分子消化器病

      Volume: 8 Pages: 220-226

  • [Journal Article] 次世代シークエンサーによる膵炎関連遺伝子の網羅的解析2009

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Journal Title

      Annual Review消化器

      Pages: 239-244

  • [Presentation] Whole exome sequenecing might become the new strategy to identify unknown mutations for pancreatitis2013

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Organizer
      2013 Annual Meeting of the American Gastroenterological Assosiation
    • Place of Presentation
      Orland
    • Year and Date
      20130518-22
  • [Presentation] 世代シークエンサーを用いた全エクソーム解析による膵炎関連遺伝子の検討2013

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      20130321-23
  • [Presentation] 慢性膵炎における遺伝子変異2011

    • Author(s)
      粂潔、正宗淳、下瀬川徹
    • Organizer
      第42回日本膵臓学会大会
    • Place of Presentation
      弘前
    • Year and Date
      20110729-30

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Published: 2015-06-25  

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