2012 Fiscal Year Final Research Report
Cross talk between the innate immune response and trans- differentiation/carcinogenesis in the gastric epithelium
| Project/Area Number |
23790766
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
ASANO Naoki 東北大学, 病院, 助教 (20526454)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 上部消化管学(食道、胃、十二指腸) |
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| Research Abstract |
Helicobacter pylori (H. pylori) infection induced Cdx2 expression via the activation of NF-κB in gastric epithelial cells. On the other hand, knocking down NOD1 enhanced this induction whereas pre-stimulation with NOD1 ligand and over-expression of TRAF3 had a suppressive role on this induction. In vivo studies with H. pylori infected mice revealed that the absence of NOD1 leads to enhanced formation of intestinal metaplasia and induction of Cdx2.
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