2012 Fiscal Year Final Research Report
Epigenetic dysregulation during development of HCC
| Project/Area Number |
23790775
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
NAGAE Genta 東京大学, 先端科学技術研究センター, 助教 (10587348)
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| Research Collaborator |
MIDORIKAWA Yutaka 日本大学, 医学部附属病院消化器外科, 助教 (10292905)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 肝臓学 / 肝臓癌 / エピジェネティクス |
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| Research Abstract |
To investigate the molecular changes during hepatocarcinogenesis, we performed integrative genomic and epigenomic analysis of HCC progressing in a nodule-in-nodule fashion. Whereas most aberrant DNA methylation was detected already in outer nodules, additional chromosomal changes were newly observed during the progression from outer nodules to inner nodules. Some HCC show methylation-dominant changes during progression conversely. These results may suggest stepwise accumulation of both genomic and epigenomic alteration in malignant progression of HCC.
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[Journal Article] Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples.2012
Author(s)
Kumano K, Arai S, Hosoi M, Taoka K,Takayama N, Otsu M, Nagae G, Ueda K,Nakazaki K, Kamikubo Y, Eto K,Aburatani H, Nakauchi H, Kurokawa M.
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Journal Title
Blood.
Volume: 119(26)
Pages: 6234-42
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[Journal Article] Whole-exome sequencing of human pancreatic cancers and characterization of genomic instability caused by MLH1 haploinsufficiency and complete deficiency.2012
Author(s)
Wang L, Tsutsumi S, Kawaguchi T, Nagasaki K, Tatsuno K, Yamamoto S, Sang F, Sonoda K, Sugawara M, Saiura A, Hirono S, Yamaue H, Miki Y, Isomura M, Totoki Y, Nagae G, Isagawa T, Ueda H, Murayama-Hosokawa S, Shibata T, Sakamoto H, Kanai Y, Kaneda A, Noda T, Aburatani H.
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Journal Title
Genome Res.
Volume: 22(2)
Pages: 208-19
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[Journal Article] Classification of Epstein-Barr virus-positive gastric cancers by definition of DNA methylation epigenotypes.2011
Author(s)
Matsusaka K, Kaneda A, Nagae G, Ushiku T, Kikuchi Y, Hino R, Uozaki H, Seto Y, Takada K, Aburatani H, Fukayama M.
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Journal Title
Cancer Res.
Volume: 71(23)
Pages: 7187-97
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[Journal Article] Methylation screening of reciprocal genome-wide UPDs identifies novel human-specific imprinted genes.2011
Author(s)
Nakabayashi K, Trujillo AM, Tayama C, Camprubi C, Yoshida W, Lapunzina P, Sanchez A, Soejima H, Aburatani H, Nagae G, Ogata T, Hata K, Monk D.
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Journal Title
Hum Mol Genet.
Volume: 20(16)
Pages: 3188-97
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[Journal Article] Tissue-specific demethylation in CpG-poor promoters during cellular differentiation.2011
Author(s)
Nagae G, Isagawa T, Shiraki N, Fujita T, Yamamoto S, Tsutsumi S, Nonaka A, Yoshiba S, Matsusaka K, Midorikawa Y, Ishikawa S, Soejima H, Fukayama M, Suemori H, Nakatsuji N, Kume S, Aburatani H.
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Journal Title
Hum Mol Genet.
Volume: 20(14)
Pages: 2710-21
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[Presentation] Epigenetics2012
Author(s)
Nagae G, Shiraki N, Kamio A, Fujita T,Kume S, Aburatani H.
Organizer
Cytosine methylation dynamics during hepatic differentiation Cold Spring Harbor Laboratory Meeting
Place of Presentation
Cold Spring Harbor, NY(USA).
Year and Date
2012-09-12
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