2013 Fiscal Year Final Research Report
Analysis of roles of LI-cadherin during the process of intrahepatic cholangiocarcinoma development and its clinical application for early detection
| Project/Area Number |
23790779
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | LI-カドヘリン / 肝内胆管癌 / BilIN |
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| Research Abstract |
In the present study, immunohistochemical analysis demonstrated that stepwise increase in LI-cadherin expression and incidence of gastrointestinal phenotype (one of mucin phenotypes) was observed with increasing the grade of biliary intraepithelial neoplasia (BilIN) (p<0.001). Logistic regression analysis revealed that the high grade BilIN (BilIN-2/3) was the only independently significant factor associated with LI-cadherin expression (odds ratio 25.9, p=0.002). The serum level of LI-cadherin was detected in 3 patients from patients with 14 intrahepatic cholangiocarcinoma (ICC). These 3 patients were TNM stage III in 1 case and TNM stage IVB in 2 cases. The results in this study suggest that the expression of LI-cadherin and gastrointestinal phenotype in high grade BilIN may be a serious lesion in the multistep process of ICC carcinogenesis, while the serum detection of LI-cadherin in ICC may be a marker for predicting late-stage disease.
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[Journal Article] Increase of fucosylated alpha-fetoprotein fraction at the onset of autoimmune hepatitis and acute liver failure
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Hepatol Res 2014
Volume: (in press)
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