2013 Fiscal Year Final Research Report
Diagnostic efficay of biopsy in autuimmune pancreatitis
Project/Area Number |
23790803
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Gastroenterology
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Research Institution | Nagoya City University |
Principal Investigator |
NAITOH Itaru 名古屋市立大学, 医学(系)研究科(研究院), 助教 (30527750)
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Project Period (FY) |
2011 – 2012
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Keywords | 自己免疫性膵炎 / IgG4関連疾患 / 生検診断 |
Research Abstract |
Our aim was to clarify which of these biopsy specimens and counting method could be a useful tool for supporting the diagnosis of autoimmune pancreatitis(AIP). We retrospectively evaluated biopsy specimens from pancreas, stomach, duodenum, duodenal papilla, colon, liver, bile duct, and minor salivary gland in 36 patients with AIP. The positive IgG4 immunostaining of the duodenal papilla in one high-power field (HPF) showed the highest sensitivity (52%) and accuracy (73%) among the 8 sites. It also showed the highest sensitivity among 4 different counting methods (IgG4 immunostaining in one HPF and 3 HPFs, both IgG4 immunostaining and IgG/IgG4 ratio in one HPF and 3 HPFs), but there were no significant differences with respect to specificity and accuracy. IgG4 immunostaining of swollen duodenal papilla with more than 10 IgG4-positive plasma cells in at least one HPF is useful for supporting the diagnosis of AIP.
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[Journal Article] A comparison of the diagnostic efficacy in type 1 autoimmune pancreatitis based on biopsy specimens from various organs2014
Author(s)
Yamashita H, Naitoh I, Nakazawa T, Hayashi K, Miyabe K, Shimizu S, Kondo M, Nishi Y, Yoshida M, Umemura S, Hori Y, Kato A, Ohara H, Takahashi S, Joh T
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Journal Title
Pancreatology
Volume: Vol14
Pages: 186-192
DOI
Peer Reviewed
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[Journal Article] Autoimmune pancreatitis presenting a short narrowing of main pancreatic duct with subsequent progression to diffuse pancreatic enlargement over 24 months; natural history of autoimmune pancreatitis2014
Author(s)
Umemura S, Naitoh I, Nakazawa T, Hayashi K, Miyabe K, Shimizu S, Kondo M, Yoshida M, Hori Y, Ohara H, Takahashi S, Joh T
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Journal Title
Peer Reviewed
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[Journal Article] Establishment of a Serum IgG4 Cut-off Value for the Differential Diagnosis of IgG4-related Sclerosing Cholangitis- A Japanese Cohort2013
Author(s)
Ohara H, Nakazawa T, Kawa S, Kamisawa T, Shimosegawa T, Uchida K, Hirano K, Nishino T, Hamano H, Kanno A, Notohara K, Hasebe O, Muraki T, Ishida E, Naitoh I, Okazaki K
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Journal Title
J Gastroenterol Hepatol
Volume: Vol28
Pages: 1247-1251
DOI
Peer Reviewed
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[Journal Article] Intraductal papillary mucinous neoplasm associated with autoimmune pancreatitis2013
Author(s)
Naitoh I, Nakazawa T, Notohara K, Miyabe K, Hayashi K, Shimizu S, Yoshida M, Yamashita H, Umemura S, Ohara H, Joh T
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Journal Title
Pancreas
Volume: Vol42
Pages: 552-554
DOI
Peer Reviewed
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[Journal Article] Clinical evaluation of international consensus diagnostic criteria for type 1 autoimmune pancreatitis in comparison with Japanese diagnostic criteria 20112013
Author(s)
Naitoh I, Nakazawa T, Hayashi K, Miyabe K, Shimizu S, Kondo H, Yoshida M, Yamashita H, Umemura S, Hori Y, Ohara H, Joh T
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Journal Title
Pancreas
Volume: Vol42
Pages: 1238-1244
DOI
Peer Reviewed
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[Journal Article] Histological evaluation of obliterative phlebitis for the diagnosis of autoimmune pancreatitis2013
Author(s)
Miyabe K, Notohara K, Nakazawa T, Hayashi K, Naitoh I, Okumura F, Shimizu S, Yoshida M, Yamashita H, Takahashi S, Ohara H, Joh T
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Journal Title
J Gastroenterol
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] Diagnostic Criteria for IgG4-related Sclerosing Cholangitis Based on Cholanigiographic Classification2012
Author(s)
Nakazawa T, Ando T, Hayashi K, Naitoh I, Okumura F, Miyabe K, Yoshida M, Shimizu S, Kondo M, Nishi Y, Yoshida M, Yamashita H, Ohara H, Joh T
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Journal Title
J Gastroenterol
Volume: Vol40
Pages: 79-87
DOI
Peer Reviewed
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[Journal Article] Clinical differences between mass-forming autoimmune pancreatitis and pancreatic cancer2012
Author(s)
Naitoh I, Nakazawa T, Hayashi K, Okumura F, Miyabe K, Shimizu S, Kondo H, Yoshida M, Yamashita H, Ohara H, Joh T
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Journal Title
Scand J Gastroenterol
Volume: Vol47
Pages: 607-613
DOI
Peer Reviewed
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[Journal Article] Small bile duct involvement in IgG4-related sclerosing cholangitis : liver biopsy and cholangiography correlation2011
Author(s)
Naitoh I, Zen Y, Nakazawa T, Ando T, Hayashi K, Okumura F, Miyabe K, Yoshida M, Nojiri S, Kanematsu T, Ohara H, Joh T
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Journal Title
J Gastroenterol
Volume: Vol46
Pages: 269-276
DOI
Peer Reviewed
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[Presentation] Endoscopic biliary intraductal ultrasonography and biopsy from bile duct and duodenal papilla in the diagnosis of IgG4-related sclerosing cholangitis2012
Author(s)
Itaru Naitoh, Takahiro Nakazawa, Katsuyuki Miyabe, Kazuki Hayashi, Shuya Shimizu, Hiromu Kondo, Michihiro Yoshida, Hiroaki Yamashita, Shuichiro Umemura, Hirotaka Ohara2), Takashi Joh
Organizer
International Digestive Endoscopy Network 2012
Place of Presentation
Seoul Korea
Year and Date
2012-07-09
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