The elucidation of the transport systems under the control of the zymogen granule membrane proteins

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790808
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Kitasato University
• Principal Investigator: KAWASHIMA Rei 北里大学, 医療衛生学部, 助教 (70392389)
• Project Period (FY): 2011 – 2012
• Keywords: チモーゲン顆粒 / メンブレントラフィック

Research Abstract

GP2 knockout (-/-) mice were utilized to clarify the mechanisms of the granule formation and exocrine secretion. Our results suggest that zymogen granule accumulation is associated with both the lysosomal dysfunction in the GP2 deficient pancreas under fasted conditions. It has been suggested thatGP2 is participated the transport systems for control of the zymogen granule membrane proteins

Research Products

• [Journal Article] Comprehensive analysis of chemokines and cytokines secreted in the peritoneal cavity during laparotomy (2012)
  • Author(s): Kawashima R, Kawamura YI, Oshio T, Mizutani N, Okada T, Kawamura YJ, Konishi F, Dohi T
  • Journal Title: J Immunoassay Immunochem Volume: 33(3) Pages: 291-301
• [Journal Article] The monoclonal antibody HCM31 specifically recognises the Sd(a) tetrasaccharide in goblet cell mucin (2012)
  • Author(s): Tsubokawa D, Goso Y, Kawashima R, Ota H, Nakamura T, Nakamura K, Sato N, Kurihara M, Dohi T, Kawamura YI, Ichikawa T, Ishihara K
  • Journal Title: FEBS Open Bio Volume: 2 Pages: 223-33
• [Journal Article] Interleukin-13 damages intestinal mucosa via TWEAK and Fn14 in mice-a pathway associated with ulcerative colitis (2011)
  • Author(s): Kawashima R, Kawamura YI, Oshio T, Son A, Yamazaki M, Hagiwara T, Okada T, Inagaki-Ohara K, Wu P, Szak S, Kawamura YJ, Konishi F, Miyake O, Yano H, Saito Y, Burkly LC, Dohi T
  • Journal Title: Gastroenterology Volume: 141(6) Pages: 2119-2129
• [Presentation] ヒト唾液ムチンに対するモノクローナル抗体の作製 (2012)
  • Author(s): 田中秀樹,角田修一,飯田泰広,川島麗,五艘行信,石原和彦,市川尊文,栗原誠
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] 神経軸索伸長制御におけるLRRK2 によるタウのリン酸化の生理的役割 (2012)
  • Author(s): 川上文貴,山田雄基,川島麗,石原和彦,市川尊文
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] Leucin-rich repeat kinase 2 (LRRK2)によるp53 のリン酸化の生理的役割に関する解析 (2012)
  • Author(s): 山田雄基,川上文貴,川島麗,市川尊文
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡
  • Year and Date: 2012-12-15
• [Presentation] TWEAK/Fn14 pathway mediates IL-13-induced intestinal epithelial cell death (2012)
  • Author(s): REI KAWASHIMA, YUKI I. KAWAMURA, TOMOYUKI OSHIO, TERUKI HAGIWARA, TOSHIHIKO OKADA, KYOKO INAGAKI-OHARA, PING WU, SUZANNE SZAK, YUTAKA J. KAWAMURA, FUMIO KONISHI, OKI MIYAKE, HIDEAKI YANO, TAKAFUMI ICHIKAWA, YUKIO SAITO, LINDA C. BURKLY and TAEKO DOHI
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-05
• [Presentation] Leucin-rich repeat kinase 2 (LRRK2)による p53 経路の調節機構に関する解析 (2012)
  • Author(s): 山田雄基,川上文貴,嶋山ひとみ,川島麗,市川尊文
  • Organizer: 第25回北里大学バイオサイエンスフォーラム
  • Place of Presentation: 東京
  • Year and Date: 2012-08-02
• [Presentation] IL-13 による消化管粘膜傷害におけるTWEAK/Fn14経路の関連性 (2012)
  • Author(s): 川島麗,土肥多恵子,河村由紀,川上文貴,市川尊文
  • Organizer: The 40thMeeting of the Japanese Society of Ulcer Research ミニワークショップ「IBD・炎症/サイトカイン」
  • Place of Presentation: 東京
  • Year and Date: 2012-07-14
• [Presentation] 急性膵炎におけるオートファジー機構とGlycoprotein2の関連性 (2012)
  • Author(s): 川島麗,川上文貴,石原和彦,市川尊文
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-20