2012 Fiscal Year Final Research Report
Investigation of the mechanisms of hepatic insul in sensitization by retinoi cacid.
| Project/Area Number |
23790819
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | レチノイン酸 / タミバロテン / インスリン抵抗性 / レプチン / STAT3 / 肝臓 / NAFLD / NASH |
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| Research Abstract |
Based on our original finding, the leptin-dependent hepatic insulinsensitization by retinoid, I investigated its precise mechanisms. It was demonstrated thatretinoid activates hepatic leptin signaling by directly inducing leptin receptor expressionvia retinoid receptor. A synthetic rtinoid, tamibarotene, also showed the same effect,suggesting its potential as a novel insulin-resistance treatment. Moreover, AntiX wasidentified as a target gene of hepatic leptin signaling, and the expression level of AntiX inthe liver was significantly correlated with the pathological status of insulin resistance.
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