2013 Fiscal Year Final Research Report
Development of observational tool of the vascular lumen vessel wall of pulmonary artery lesion in patients with pulmonary hypertension.
| Project/Area Number |
23790827
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
MIURA YUTAKA 東北大学, 大学病院, 助教 (80598409)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 肺高血圧症 / 血管内皮イメージ / 右心機能 |
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| Research Abstract |
(1) OCT images of the pulmonary artery lesion in patients with pulmonary hypertension showed network-shaped web image in patients with chronic thromboembolic pulmonary hypertension (CTEPH).Percutaneous transluminal pulmonary angioplasty (PTPA) significantly improved symptom, BNP levels, pulmonary hemodynamics. Also, PTPA group had significantly better prognosis compared with historical group (P<0.05).
(2) In pulmonary hypertension animal models, we examined the small pulmonary artery and pulmonary artery main trunk lesions, and the right ventricular (RV) function. RV remodeling occurs early in PH development through fibrosis, perivascular remodeling, capillary rarefaction and autophagy, for which eNOS pathway and collagen metabolism may be involved.
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Research Products
(9 results)
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[Journal Article] Enhanced[18F]fluorodeoxyglucose accumulation in the right ventricular free wall predicts long-term prognosis of patients with pulmonary hypertension : a preliminary observational study2014
Author(s)
Tatebe Shunsuke, Fukumoto Yoshihiro, Oikawa-Wakayama Minako, Sugimura Koichiro, Satoh Kimio, Miura Yutaka, Aoki Tatsuo, Nochioka Kotaro, Miura Masanobu, Yamamoto Saori, Tashiro Manabu, Kagaya Yutaka, Shimokawa Hiroaki
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Journal Title
European Heart Journal Cardiovascular Imaging
Volume: (ahead of print)
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[Journal Article] Impact of physical activity on cardiovascular events in patients with chronic heart failure. A multicenter prospective cohort study2013
Author(s)
Miura Yutaka, Fukumoto Yoshihiro, Miura Toshiro, Shimada Kazunori, Asakura Masanori, Kadokami Toshiaki, Ando Sin-ichi, Miyata Satoshi, Sakata Yasuhiko, Daida Hiroyuki, Matsuzaki Masunori, Yasuda Satoshi, Kitakaze Masafumi, Shimokawa Hiroaki
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Journal Title
Circulation Journal
Volume: 77(12)
Pages: 2963-72
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[Journal Article] Optical coherence tomography is superior to intravascular ultrasound for diagnosis of distal-type chronic thromboembolic pulmonary hypertension2013
Author(s)
Tatebe Shunsuke, Fukumoto Yoshihiro, Sugimura Koichiro, Miura Yutaka, Nochioka Kotaro, Aoki Tatsuo, Miura Masanobu, Yamamoto Saori, Yaoita Nobuhiro, Satoh Kimio, Shimokawa Hiroaki
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Journal Title
Circulation Journal
Volume: 77(4)
Pages: 1081-1083
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