The role of Notch signals and FGF23 in cardio-renal interaction.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790832
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Gunma University
• Principal Investigator: NAKAHARA Takehiro 群馬大学, 医学部, 医員 (00599540)
• Project Period (FY): 2011 – 2012
• Keywords: 循環器・腎臓病 / FGF23 / 血管石灰化

Research Abstract

In order to evaluate the effect of Fibroblast Growth Factor 23 (FGF23) in cardio-renal interaction, we examined several basic analysis. As a result we identified that FGF23 induced Osteoprotegerin (OPG), decoy of RANKL. OPG prevent RANK-RANKL interaction and protect vascular calcification. In conclusion, FGF23, increased from early stage of CKD, may protect vascular calcification.

Research Products

• [Journal Article] Doppler echocardiography may provide a potentially life-saving screening of anomalous origin of coronary artery inyoung athletes (2012)
  • Author(s): Nakahara T, Takahashi-Tateno R, Hasegawa A, Kimura T, Tsushima Y,Murakami M, Kurabayashi M.
  • Journal Title: Int J Cardiol Volume: 156(1) Pages: 104-5
  • Peer Reviewed
• [Journal Article] Cardiac computed tomography can diagnose the tricuspid valve pouch (2012)
  • Author(s): Nakahara T, Niwamae N, Kurosawa K, Kurabayashi M
  • Journal Title: Int J Cardiol Volume: 157(3) Pages: e50-1
  • Peer Reviewed
• [Journal Article] Estimation of the left ventricular diastolic function with cardiac MDCT: correlationof the slope of the time-enhancement-curve with the mitral annulus diastolic velocity. (2012)
  • Author(s): Takahara T, Jinzaki M, Fukuda N, Takahashi Y, Ishihara T, Takada A, Suzuki K, Manita M, Imanari T, Kanesawa N, Kuribayashi S, Kurabayashi M
  • Journal Title: Eur J Radiol Volume: 81(2) Pages: 234-8
  • Peer Reviewed
• [Journal Article] Justification for Atherosclerosis Regression Treatment (JART) Investigators. Effect of intensive lipid-lowering therapy with rosuvastatin on progression of carotid intima-media thickness in Japanese patients: Justification for Atherosclerosis Regression Treatment (JART) study (2012)
  • Author(s): Nohara R, Daida H, Hata M, Kaku K, Kawamori R, Kishimoto J, Kurabayashi M, 他、Nakahara T
  • Journal Title: Circ J Volume: 76(1) Pages: 221-9
  • Peer Reviewed
• [Presentation] Replacement injection methods may enable better visualization in the right heart (2012)
  • Author(s): Takehiro Nakahara, Nogiku Niwamae, Norimichi Koidatabashi1,Ryoutatrou Seki,Tadashi Nakajima, Tatsuya Iso, Yuuichirou Saito, Yoshiaki Kaneko, Masashi Arai, Yoshihito Tsushima, Masahiko Kurabayashi
  • Organizer: 日本循環器学会第76回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20120316-0318
• [Presentation] Can Cardiac CT evaluate Left VentricularDiastolic Function? Correlation of theSlope of the Time-Enhancement-Curve with the Mitral Annulus Diastolic Velocity (2012)
  • Author(s): Takehiro Nakahara, Masahiro Jinzaki , Nobuaki Fukuda, Yasuyuki Takahashi, Toshihiro Ishihara, Atsuko Takada, Kenichi Suzuki, Mamoru Manita, Tetsurou Imanari,Norio Kanesawa, Sachio Kuribayashi, Masahiko Kurabayashi
  • Organizer: 日本循環器学会第76回学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20120316-0318
• [Presentation] Fibroblast growth factor 23 inhibits osteogenic differentiation of vascular smooth muscle cells: A protective role against vascular calcification (2012)
  • Author(s): Takehiro Nakahara, Keiko Kawai-Kowase, Hiroki Matsui, Tatsuya Iso, Toshihiro Utsugi, Shoichi Tomono, Akira ogawa,Kanesawa Norio, Masashi Arai, Masahiko Kurabayashi
  • Organizer: 日本循環器学会第77回学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20120315-0317
• [Presentation] Fibroblast growth factor 23 inhibits osteogenic differentiation of vascular smooth muscle cells: A protective role against vascular calcification? (2012)
  • Author(s): Takehiro Nakahar
  • Organizer: Annual Meeting of ATVB Early Career Networking Reception
  • Place of Presentation: (Invite presentation) USA, 2012
  • Year and Date: 20120000
• [Presentation] Fibroblast Growth Factor23 Inhibits Osteogenic Differentiation Of Vascular Smooth Muscle Cells:A Protective Role Against Vasucular Calcification? (2012)
  • Author(s): Nakahara T.,Kawai-Kowase K,Matsui H.,Iso T.,Utsugi T.,TOmono S.,Arai M.,Kurabayashi M
  • Organizer: Annual Meeting of American Heart Association Scientific Sessions 2012
  • Place of Presentation: USA
  • Year and Date: 20120000
• [Presentation] Replacement injection methods may enable better visualization in the right heart (2012)
  • Author(s): Takehiro Nakahara, Masahiro Jinzaki, Nogiku Niwamae, Ryoutarou Seki ,Norimichi Koitabashi, Tadasi Nakajima, Tasuya Iso, Yuuichirou Saito, yoshiaki kaneko, Masashi Arai, Yoshito Tsushima, Sachio Kuribayashi, Masahiko Kurabayashi
  • Organizer: Annual Meeting of ASCI Asian Society ofCardiovascular Imaging 2012
  • Place of Presentation: (Best young investigator award session), Thailand
  • Year and Date: 20120000
• [Presentation] DualEnergyを用いた心筋perfusionの可能性についてー心筋SPECTとの比較- (2011)
  • Author(s): 中原健裕、外山卓二、関亮太郎、小板橋紀通、庭前野菊、中島忠、斉藤勇一郎、金古善明、新井昌史、対馬義人、倉林正彦
  • Organizer: 第51回日本核医学会学術総会
  • Place of Presentation: 筑波
  • Year and Date: 20111027-29
• [Presentation] Replacement injection methods may enable better visualization in the right heart (2011)
  • Author(s): Takehiro Nakahara, Nogiku Niwamae, Tadashi Nakajima, Tatsuya Iso, Yuuichirou Saito, Yoshiaki Kaneko, Masashi Arai, Yoshihito Tsushima, Keigo Endo, Masahiko Kurabayashi
  • Organizer: Annual Meeting of SCCT Society ofCadiovascular Computed tomoguraphy
  • Place of Presentation: (Young Investigator Award session), USA
  • Year and Date: 20110000
• [Presentation] Can Cardiac CT evaluate Left Ventricular Diastolic Function? Correlation of the Slope of the Time-Enhancement-Curve with the Mitral Annulus Diastolic Velocity (2011)
  • Author(s): Takehiro Nakahara, Masahiro Jinzaki , Nobuaki Fukuda, Yasuyuki Takahashi, Toshihiro Ishihara, Atsuko Takada, Kenichi Suzuki, Mamoru Manita, Tetsurou Imanari, Norio Kanesawa, Sachio Kuribayashi, Masahiko Kurabayashi
  • Organizer: Annual Meeting of ASCI Asian Society of Cardiovascular Imaging 2011
  • Place of Presentation: (Best young investigator award session), Hong-Kong
  • Year and Date: 20110000