2013 Fiscal Year Final Research Report
Interorgan communication between heart and kidney in the development of cardiorenal diseases
| Project/Area Number |
23790835
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Keywords | マクロファージ / 炎症 / 集合間上皮細胞 / 腎臓病 |
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| Research Abstract |
We revealed a novel mechanism of renal initial inflammation. Renal collecting duct epithelial cells have been reported as key cells in water homeostasis. In addition to this basic function, we showed collecting duct cells induced renal initial inflammation in response to renal injury by recruiting inflammatory macrophages into kidney from bone marrow. In this process, transcription factor KLF5 is activated in collecting duct cells and secretes S100a8 and S100a9 which can recruit inflammatory cells.
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Research Products
(24 results)
