2012 Fiscal Year Final Research Report
Mechanism of cardiac remodeling through modulation of angiogenesis.
| Project/Area Number |
23790846
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
OHASHI Koji 名古屋大学, 医学系研究科, 寄附講座助教 (10595515)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 血管新生 / 心筋リモデリング |
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| Research Abstract |
In the process of investigation for anti-cardiac remodeling-function of Adiponectin, we identified a C1q/TNF-related protein family 9 (CTRP9), which is a member of adiponectin paralogs (C1q/TNF-related protein family),as a novel adipocytokine. Administration of CTRP9 ameliorated cardiac remodeling after ischemia reperfusion injury via AMP-kinase signaling.
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[Journal Article] Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation.2013
Author(s)
Uemura Y, Shibata R, Ohashi K,Enomoto T, Kambara T, Yamamoto T, Ogura Y, Yuasa D, Joki Y, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N.
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Journal Title
FASEB J.
Volume: 27
Pages: 25-33
Peer Reviewed
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[Journal Article] Therapeutic Impact of Follistatin-like 1 on Myocardial Ischemic Injury in Preclinical Animal Models2012
Author(s)
Ogura Y, Ouchi N, Ohashi K,Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T
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Journal Title
Circulation
Volume: 126
Pages: 1728-38
Peer Reviewed
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[Journal Article] CTRP9 protein protects against myocardial injury following ischemia-reperfusion through AMP-activated protein kinase (AMPK)-dependent mechanism2012
Author(s)
Kambara T, Ohashi K,Shibata R, Ogura Y, Maruyama S, Enomoto T, Uemura Y, Shimizu Y, Yuasa D, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N.
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Journal Title
J Biol Chem.
Volume: 287
Pages: 18965-73
Peer Reviewed
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[Journal Article] Fat-derived factor omentin stimulates endothelial cell function and ischemia-induced revascularization via endothelial nitric oxide synthase-dependent mechanism2012
Author(s)
Maruyama S, Shibata R, Kikuchi R, Izumiya Y, Rokutanda T, Araki S, Kataoka Y, Ohashi K, Daida H, Kihara S, Ogawa H, Murohara T, Ouchi N
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Journal Title
J Biol Chem
Volume: 287
Pages: 408-17
Peer Reviewed
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[Journal Article] Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload.2011
Author(s)
Shimano M, Ouchi N, Nakamura K, van Wijk B, Ohashi K, Asaumi Y, Higuchi A, Pimentel DR, Sam F, Murohara T, van den Hoff MJ, Walsh K.
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Journal Title
Proc Natl Acad Sci U S A.
Volume: 108
Pages: E899-906
Peer Reviewed
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