2012 Fiscal Year Final Research Report
Investigation of molecular mechanisms of athero-protection by regulatory T cells and development of novel strategies for preventing atherosclerosis
| Project/Area Number |
23790849
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kobe University |
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Principal Investigator |
SASAKI Naoto 神戸大学, 医学研究科, 助教 (00514746)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 動脈硬化症 / 炎症 / 免疫細胞 |
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| Research Abstract |
We investigated the role of regulatoryT cells (Tregs) in the development of atherosclerosis. Under hypercholesterolemia, Treg depletion led to augmented effector T cell responses and a significant decrease in plasma cholesterol levels, and did not affect the atherosclerotic lesion size. Ultraviolet B (UVB) irradiation significantly reduced atherosclerosis development in ApoE-/-mice compared to controls. This was associated with systemic expansion of Tregs exhibiting potent suppressor function and suppressed effector T cell responses.
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