2012 Fiscal Year Final Research Report

Development of new heart failure therapies that target oxygen metabolism

Research Project

Project/Area Number	23790850
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Circulatory organs internal medicine
Research Institution	Osaka University
Principal Investigator	TAKEDA Toshihiro 大阪大学, 大学院・医学系研究科, 特任助教 (70506493)
Project Period (FY)	2011 – 2012
Keywords	ヘモグロビン / 酸素代謝 / 運動耐容能
Research Abstract	The purpose of this study is to investigate the new chemicals that reduce hemoglobinoxygen affinity and improve the exercise intolerance of the patients with chronic heart failure from RSR13. RSR13 exerts its effect by fitting its aromatic ring in hemoglobinpocket. By enlarging the side chain of the aromatic ring of RSR13, the effect of new chemicals was increased. However, hemoglobin was denatured if the side chain was too large. In addition, by changing the skeleton RSR13, the effect of new chemicals were also increased.