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2012 Fiscal Year Final Research Report

To explore the biomarkers which determine the quality of high density lipopotein

Research Project

  • PDF
Project/Area Number 23790853
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionKobe University

Principal Investigator

YASUDA Tomoyuki  神戸大学, 医学部附属病院, 特定助教 (20457047)

Project Period (FY) 2011 – 2012
Keywords分子血管病態学
Research Abstract

I n the present study, we used rabbit’s and human’s samples for evaluating HDL quality. In basic study, we used the myocardial infarction-prone Watanabe heritable hyperlipidemic (WHHL-MI) rabbits which develop atherosclerotic lesion by month and control Japanese white (JW) rabbits which are healthy control. We evaluated the quantitative or qualitative alteration of HDL in the same individual rabbit. Paraoxonase activity assay, as an antioxidant property of HDL, and cholesterol efflux capacity assay were performed for evaluating HDL quality. There were no differences in HDL quality between 2 rabbit models. HDL qualitative evaluation was performed using the dyslipidemia patients’ serum before and after statin treatment. Statin increased HDL-C levels, and the cholesterol efflux capacity and antioxidant potential of increased HDL were maintained. As mentioned above, both HDL quantities and qualities analysis would be important for evaluating the risk of atherosclerosis.

  • Research Products

    (2 results)

All 2013 Other

All Journal Article (1 results) Presentation (1 results)

  • [Journal Article] Pitavastatin increases HDL particles functionally-preserved with cholesterol efflux capacity and antioxidativeaction in dyslipidemia patients

    • Author(s)
      Maki Miyamoto-Sasaki, Tomoyuki Yasuda,et al
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 掲載確定

  • [Presentation] Pitavastatin increases HDL particles with preserved anti-atherosclerotic properties in dyslipidemicpatients2013

    • Author(s)
      Tomoyuki Yasudaet al
    • Organizer
      the American College of Cardiology 62nd Annual Scientific Session
    • Place of Presentation
      San Francisco
    • Year and Date
      2013-03-09

URL: 

Published: 2014-09-25  

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