2013 Fiscal Year Final Research Report
Molecular mechanism of anti-inflammatory properties of parasympathetic nervous system and its application in pharmacotherapy of abdominal aortic aneurysm
| Project/Area Number |
23790858
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Kochi University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 生体機能利用 / 心機能保護 / コリンエステラーゼ阻害剤 / アセチルコリン |
|---|
| Research Abstract |
In the present study, we investigated the effect of donepezil, an acetylcholinesterase inhibitor, on the endotoxin-induced inflammation in macrophage cells. As results, donepezil reduced the expression and secretion of pro-inflammatory cytokines by attenuating the LPS-induced nuclear translocation of NF-kB. Neither acetylcholine nor other acetylcholinesterase inhibitors reproduced the anti-inflammatory action of donepezil, indicating that donepezil directly affects cells via a mechanism which is independent of its pharmacological property of acetylcholinesterase inhibition.
|
