2013 Fiscal Year Final Research Report
Molecular mechanism of anti-inflammatory properties of parasympathetic nervous system and its application in pharmacotherapy of abdominal aortic aneurysm
| Project/Area Number |
23790858
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生体機能利用 / 心機能保護 / コリンエステラーゼ阻害剤 / アセチルコリン |
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| Research Abstract |
In the present study, we investigated the effect of donepezil, an acetylcholinesterase inhibitor, on the endotoxin-induced inflammation in macrophage cells. As results, donepezil reduced the expression and secretion of pro-inflammatory cytokines by attenuating the LPS-induced nuclear translocation of NF-kB. Neither acetylcholine nor other acetylcholinesterase inhibitors reproduced the anti-inflammatory action of donepezil, indicating that donepezil directly affects cells via a mechanism which is independent of its pharmacological property of acetylcholinesterase inhibition.
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Research Products
(13 results)
