2012 Fiscal Year Final Research Report
Development of Novel Nano-medicine for Aortic Aneurysm regulating Monocyte/Macrophage M1/M2 Polarit
| Project/Area Number |
23790861
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 分子血管病態学 / 大動脈瘤 / マクロファージ / ナノ医療 |
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| Research Abstract |
The applicant showed the role of inflammatory Ly6Chighmonocytes/macrophages in the development of abdominal aneurysm, and showed that nanoparticle-mediated delivery of a statin into circulation monocyte inhibited the recruitment of inflammatory monocytes and the development of abdominal aneurysm in an ApoE-deficient mouse model
The applicant showed the role of inflammatory Ly6Chighmonocytes/macrophages in the development of abdominal aneurysm, and showed that nanoparticle-mediated delivery of a statin into circulation monocyte inhibited the recruitment of inflammatory monocytes and the development of abdominal aneurysm in an ApoE-deficient mouse model.
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