2012 Fiscal Year Final Research Report
Analyses of Signal pathway and medical strategy for vascularendothelial dysfunction
| Project/Area Number |
23790865
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 内皮機能 / ミトコンドリア / AMPK |
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| Research Abstract |
We identified that Telmisartan, a hypertensive medicine and iseffective in preventing cardiovascular events in high-risk patients, could activate humancoronary artery endothelial cells (HCAECs) by modulating mitochondrial function.Telmisartan improves endothelial dysfunction through the upregutation of AMPK signaling,a key regulator of cellular energy adaptation, in HCAECs. In vivo, Telmisartan alsoimproved endothelial dysfunction in KKAY mouse model.
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