The new strategy for protection of cardiomyocyte injury using HMGB1 knock out mouse

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790866
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Fukushima Medical University
• Principal Investigator: SUZUKI Satoshi 福島県立医科大学, 医学部循環器・血液内科学講座, 助教 (60536944)
• Project Period (FY): 2011 – 2012
• Keywords: 心筋梗塞後リモデリング / 心筋細胞再生 / HMGB1

Research Abstract

Because we could not get the results which we hypothesized previously, we have improved some points of research methods. We clarified that the blood concentration of high mobility group box protein 1 (HMGB1) increased rapidly in a few days after myocardial infarction (MI), therefore we have decided to hasten the harvest point of heart after MI creation. Moreover, mortality was high in the first protocol, and we increased the number of transfection cells in order to increase the survival rate. We are currently in progress experiments.

Research Products

• [Journal Article] Long pentraxin PTX3 exacerbates pressure overload-induced left ventricular dysfunction (2013)
  • Author(s): Suzuki S, Shishido T, Funayama A, Netsu S, Ishino M, Kitahara T, Sasaki T, Katoh S, Otaki Y, Watanabe T, Shibata Y, Mantovani A, Takeishi Y, Kubota I
  • Journal Title: PLoS ONE Volume: 8(1) Pages: e53133
• [Journal Article] Adaptive servoventilation improves cardiorenal function and prognosis in heart failure patients with chronic kidney disease and sleep-disorderedbreathing (2013)
  • Author(s): Owada T, Yoshihisa A, Yamauchi H, Iwaya S, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: J Card Fail Volume: 19 (4) Pages: 225-232
• [Journal Article] Left ventricular plasty improved cardiac function in a case of takotsubo cardiomyopathy with persistent aneurysm (2013)
  • Author(s): Miyata M, Nakazato K, Sakamoto N, Suzuki S, Kamiyama Y, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: J Cardiol Case Volume: 7 (5) Pages: e133-e136
• [Journal Article] Impact of adaptive servo-ventilation on cardiovascular function and prognosis in heart failure patients with preserved left ventricular ejection fraction and sleep-disordered breathing (2013)
  • Author(s): Yoshihisa A, Suzuki S, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Eur J Heart Fail Volume: 15 (5) Pages: 543-550
• [Journal Article] 'A single night' beneficial effects of adaptive servo-ventilation on cardiac overload, sympathetic nervous activity, and myocardial damage in patients with chronic heart failure and sleep-disordered breathing (2012)
  • Author(s): Yoshihisa A, Suzuki S, Miyata M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Circ J Volume: 76 (9) Pages: 2153-2158
• [Journal Article] Adaptive servo ventilation improves Cheyne-Stokes respiration, cardiac function, and prognosis in chronic heart failure patients with cardiac resynchronization therapy (2012)
  • Author(s): Miyata M, Yoshihisa A, Suzuki S, Yamada S, Kamioka M, Kamiyama Y, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: J Cardiol Volume: 60(3) Pages: 222-227
• [Journal Article] Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice (2012)
  • Author(s): Hirose M, Takeishi Y, Nakada T, Shimojo H, Kashihara T, Nishio A, Suzuki S, Mende U, Matsumoto K, Matsushita N, Taira E, Sato F, Yamada M
  • Journal Title: PLoS One Volume: 7(12) Pages: e52667
• [Journal Article] 8-Hydroxy-2'-deoxyguanosine is a prognostic mediator for cardiac event (2011)
  • Author(s): Suzuki S, Shishido T, Ishino M, Katoh S, Sasaki T, Nishiyama S, Miyashita T, Miyamoto T, Nitobe J, Watanabe T, Takeishi Y, Kubota I
  • Journal Title: Eur J Clin Invest Volume: 41(7) Pages: 759-766
• [Journal Article] Adaptive servo ventilation improves cardiac dysfunction and prognosis in chronic heart failure patients with Cheyne-Stokes respiration (2011)
  • Author(s): Yoshihisa A, Shimizu T, Owada T, Nakamura Y, Iwaya S, Yamauchi H, Miyata M, Hoshino Y, Sato T, Suzuki S, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Journal Title: Int Heart J Volume: 52(4) Pages: 218-223
• [Journal Article] Differential regulation of diacylglycerol kinase isoform in human failing hearts (2011)
  • Author(s): Bilim O, Shishido T, Toyama S, Suzuki S, Sasaki T, Kitahara T, Sadahiro M, Takeishi Y, Kubota I
  • Journal Title: J Cardiothorac Surg Volume: 6 Pages: 65
• [Presentation] Selective vasopressin V2 receptor antagonist, tolvaptan, for treatment of acute decompensated heart failure: comparison with intravenous carperitide infusion (2013)
  • Author(s): Suzuki S, Takeishi Y
  • Organizer: 第77回日本循環器学会学術集会 (The 77th Annual Scientific Meeting of the Japanese Circulation Society)
  • Place of Presentation: 横浜
  • Year and Date: 20130300
• [Presentation] A single night use of adaptive servo ventilation improves renal function in heart failure patients with sleep disordered breathing (2012)
  • Author(s): Suzuki S, Yoshihisa A, Sugimoto K, Yamaki T, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2012
  • Place of Presentation: Munich, Germany
  • Year and Date: 20120800
• [Presentation] Anemia has significant impacts for adaptive servo ventilation therapy on heart failure patients with Cheyne-Stokes respiration (2012)
  • Author(s): Suzuki S, Yoshihisa A, Miyata M, Sugimoto K, Yamaki T, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2012
  • Place of Presentation: Munich, Germany
  • Year and Date: 20120800
• [Presentation] Adaptive servo ventilation improves long-term prognosis in heart failure patients with preserved left ventricular ejection fraction and sleep disordered breathing (2012)
  • Author(s): Suzuki S, Yoshihisa A, Miyata M, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2012
  • Place of Presentation: Munich, Germany
  • Year and Date: 20120800
• [Presentation] Overnight beneficial impacts of adaptive servo ventilation on cardiac overload, sympathetic nervous activity, and myocardial damage in chronic heart failure patients with Cheyne-Stokes respiration (2012)
  • Author(s): Suzuki S, Yoshihisa A, Miyata M, Sugimoto K, Kunii H, Yamaki T, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Congress of the European Society of Cardiology 2012
  • Place of Presentation: Munich, Germany
  • Year and Date: 20120800
• [Presentation] Effect of pentraxin 3 on pressure overload-induced left ventricular hypertrophy. Basic Cardiovascular Sciences 2012 Scientific Sessions (BCVS 2012) (2012)
  • Author(s): Suzuki S, Shishido T, Funayama A, Netsu S, Takeishi Y
  • Organizer: Frontiers in Cardiovascular Science and Novel Therapy
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 20120700
• [Presentation] Adaptive servo ventilation has acute anti-oxidative and anti-inflammatory effects in heart failure patients with Cheyne-Stokes respiration (2012)
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第76回日本循環器学会学術集会 (The 76th Annual Scientific Meeting of the Japanese Circulation Society)
  • Place of Presentation: 福岡
  • Year and Date: 20120300
• [Presentation] Anemia has significant impacts for adaptive servo ventilation therapy on heart failure patients with Cheyne-Stokes respiration (2012)
  • Author(s): Suzuki S, Yoshihisa A, Yamaki T, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第76回日本循環器学会学術集会 (The 76th Annual Scientific Meeting of the Japanese Circulation Society)
  • Place of Presentation: 福岡
  • Year and Date: 20120300