Investigation of cardio-protective effects of PDE3A on chronic heart failure

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790867
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Circulatory organs internal medicine
• Research Institution: Fukushima Medical University
• Principal Investigator: OIKAWA Masayoshi 福島県立医科大学, 医学部循環器・血液内科学講座, 助教 (30457775)
• Project Period (FY): 2011 – 2012
• Keywords: 分子心臓病学

Research Abstract

I revealed a novel mechanisms of PDE3A for preventing hearts from ischemia/reperfusion injury and angiotensin II-induced cardiac remodeling using cardiospecific PDE3A overexpression mice.

Research Products

• [Journal Article] p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction (2012)
  • Author(s): Le N, Takei Y, Shishido T, Woo C, Chang E, Heo K, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina C, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J
  • Journal Title: Circ Res Volume: 110(4) Pages: 536-550
• [Journal Article] Soluble amyloid precursor protein 770 is released from inflamed endothelial cells and activated platelets:a novel biomarker for acute coronary syndrome. (2012)
  • Author(s): Kitazume S, Yoshihisa A, Yamaki T, Oikawa M, Tachida Y, Ogawa K, Imamaki R, Hagiwara Y, Kinoshita N, Takeishi Y, Furukawa K, Tomita N, Arai H, Iwata N, Saido T, Yamamoto N, Taniguchi N
  • Journal Title: J Biol Chem Volume: 287 (48) Pages: 40817-40825
• [Journal Article] Cyclic nucleotide phosphodiesterase 1A (2011)
  • Author(s): Miller C, Cai Y, Oikawa M, Thomas T, Dostmann W, Zaccolo M, Fujiwara K, Yan C:
  • Journal Title: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart. Basic Res Cardiol Volume: 106 (6) Pages: 1023-1039
• [Journal Article] Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice (2011)
  • Author(s): Satoh K, Nigro P, Zeidan A, Soe N, Jaffre F, Oikawa M, O'Dell M, Cui Z, Menon P, Lu Y, Mohan A, Yan C, Blaxall B, Berk B
  • Journal Title: Arterioscl Throm Vas Volume: 31(5) Pages: 1116-1123
• [Presentation] Soluble amyloid precursor protein 770 is a novel marker for acute coronary syndrome (2013)
  • Author(s): Yoshihisa A, Yamaki T, Kitazume S, Mizukami H, Oikawa M, Sakamoto N, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130300
• [Presentation] Soluble amyloid precursor protein 770 is an early marker for diagnosis of acute coronary syndrome. (2013)
  • Author(s): Yamaki T, Oikawa M, Yoshihisa A, Kitazume S, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130300
• [Presentation] Phoshodiesterase 3A1 protects the heart against angiotensin II-induced cardiac injury via regulating interaction between ss-adrenergic and angiotensin II pathways (2013)
  • Author(s): Iwaya S, Oikawa M, Owada T, Takeishi Y
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130300
• [Presentation] The diffiential roles of pericardial and abdominal adipose tissues in coronary plaque burden and calcification assessed by computed tomography (2013)
  • Author(s): Oikawa M, Owada T, Yamauchi H, Takeishi Y
  • Organizer: 第77回日本循環器学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 20130300
• [Presentation] Effects of overexpressed phosphodiesterase 3A on cardiac remodeling and cardioprotection against ischemia/repersfusion injury (2012)
  • Author(s): Oikawa M, Lim S, Yan C, Takeishi Y
  • Organizer: The 29th Annual Meeting of the International Society for Heart Research (ISHR) Japanese Section
  • Place of Presentation: Fukuoka, Japan
  • Year and Date: 20121000
• [Presentation] Overexpressed phoshodiesterase 3A1 protects the heart against angiotensin II-induced cardiac injury via regulating interaction between ss-adrenergic and angiotensin II signaling pathways (2012)
  • Author(s): Oikawa M, Iwaya S, Yan C, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2012
  • Place of Presentation: Los Angeles, California, USA
  • Year and Date: 20121000
• [Presentation] Plasma carnitine level in heart failure patients with sleep disordered breathing (2012)
  • Author(s): Miyata M, Yoshihisa A, Yamaki T, Iwaya S, Owada T, Suzuki S, Oikawa M, Sugimoto K, Nakazato K, Suzuki H, Saitoh S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2012
  • Place of Presentation: Los Angeles, California, USA
  • Year and Date: 20121000
• [Presentation] Soluble amyloid precursor protein 770 is a novel marker for diagnosis of acute coronary syndrome (2012)
  • Author(s): Yamaki T, Yoshihisa A, Miyata M, Suzuki S, Oikawa M, Sugimoto K, Kunii H, Nakazato K, Suzuki H, Saitoh S, Kitazume S, Takeishi Y
  • Organizer: Scientific Sessions of American Heart Association 2012
  • Place of Presentation: Los Angeles, California, USA
  • Year and Date: 20121000
• [Presentation] Overexpressed phoshodiesterase 3A regulates cardiac function and protects hearts from ischemia/reperfusion injur (2012)
  • Author(s): Oikawa M, Lim S, Knight W, Miller C, Cai Y, Abe J, Takeishi Y, Yan C
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 20120300
• [Presentation] Overexpressed phoshodiesterase 3A regulates cardiac function and protects hearts from ischemia/reperfusion injury (2011)
  • Author(s): Oikawa M, Lim S, Jeon K, Knight W, Miller C, Cai Y, Blaxall B, Abe J, Takeishi Y, Yan C
  • Organizer: Scientific Sessions of American Heart Association 2011
  • Place of Presentation: Orlando, Florida USA
  • Year and Date: 20111000
• [Presentation] Diagnosis of ischemia by strain rate in 3D adenosine-stress echocardiography: Which index is the most useful to identify adenosine-induced ischemia? (2011)
  • Author(s): Iwai-Takano M, Kobayashi A, Oikawa M, Sugimoto K, Takeishi Y
  • Organizer: 第75回日本循環器学会学術集会
  • Year and Date: 20110800
• [Book] C.慢性心不全の治療11.鉄欠乏状態の慢性心不全患者において、鉄欠乏性貧血治療薬ferric carboxymaltoseの静注は症状を改善するか? (2012)
  • Author(s): 及川雅啓, 斎藤修一, 竹石恭知
  • Total Pages: 219-222
  • Publisher: 中外医学社
• [Remarks] 福島県立医科大学循環器・血液内科ホームページにおいて、研究成果を報告している