2012 Fiscal Year Final Research Report
The regulation of local corticosteroid synthesis and its pathophysiological effect in the heart.
| Project/Area Number |
23790881
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Jikei University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | アルドステロン / グルコース / インスリンシグナル / 心筋細胞 |
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| Research Abstract |
Aldosterone plays a pivotal role in the pathogenesis of heart failure. We herein investigated the regulation of the local aldosterone synthesis and its pathophysiological effects in the heart. We demonstrated that high glucose conditions promote the expression of aldosterone synthase in cardiomyocytes. Moreover, a short-term aldosterone stimulation is found to be cardioprotective through the acute activation of insulin signaling in a mineralocorticoid receptor-independent manner. These results provide new insight into the previously unknown role of aldosterone, as a compensatory mechanism under the pathological conditions, such as heart failure, where glucose becomes an important preferential substrate for metabolism and ATP generation.
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[Journal Article] Biphasic Action of Aldosterone on Akt Signaling in Cardiomyocytes2012
Author(s)
Nagoshi T*,Date T, Fujisaki M, Yoshino T, Sekiyama H, Ogawa K, Kayama Y, Minai K, Komukai K, Ogawa T, Yoshimura M
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Journal Title
Horm Metab Res
Volume: 44
Pages: 931-937
DOI
Peer Reviewed
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[Journal Article] Cardiac tamponade as an independent condition affecting the relationship between the plasma B-type natriuretic peptide levels and cardiac function.2012
Author(s)
Minai K, Komukai K, Arase S, Nagoshi T, Matsuo S, Ogawa K, Kayama Y, Inada K, Tanigawa SI, Takemoto T, Sekiyama H, Date T, Ogawa T, Taniguchi I,Yoshimura M
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Journal Title
Heart Vessels
Volume: (in press)
Peer Reviewed
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[Journal Article] Contribution of extracardiac factors to the inconsistency between plasma b-type natriuretic peptide levels and the severity of pulmonary congestion on chest x-rays in the diagnosis of heart failure.2012
Author(s)
Nakane T, Kawai M, Komukai K, Kayama Y, Matsuo S, Nagoshi T,Minai K, Date T, Ogawa T, Yagi H, Yoshimura M
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Journal Title
Intern. Med
Volume: 51
Pages: 239-248
Peer Reviewed
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[Journal Article] Impact of body mass index on clinical outcome in patients hospitalized with congestive heart failure.2012
Author(s)
Komukai K, Minai K, Arase S, Ogawa T, Nakane T, Nagoshi T, Kayama Y, Abe Y, Morimoto S, Ogawa K, Fujii S, Sekiyama H, Date T, Kawai M, Hongo K, Taniguchi I, Yoshimura M
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Journal Title
Circ J.
Volume: 76
Pages: 145-151
Peer Reviewed
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[Presentation] Biphasic Character of Aldosterone in Cardiomyocytes Through the Akt Signaling Activation.2011
Author(s)
Nagoshi T, Date T, Fujisaki M, Yoshino T, Sekiyama H, Ogawa K, Minai K, Komukai K, Ogawa T, Yoshimura M
Organizer
Circulation2011;124: Abstract 11268, American Heart Assosication
Place of Presentation
Orlando
Year and Date
2011-11-14
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