• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2012 Fiscal Year Final Research Report

Role of naofen, a novel WD 40-repeat protein, in diabetic angiopathy

Research Project

  • PDF
Project/Area Number 23790885
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionAichi Medical University

Principal Investigator

HUANG Lei  愛知医科大学, 医学部, 助教 (00556095)

Project Period (FY) 2011 – 2012
Keywords糖尿病 / 血管障害 / 酸化ストレス / p38 MAPK
Research Abstract

High glucose was shown to elicit reactive oxygen species (ROS) production and induce apoptosis accompanied by activation of p38 mitogen-activated protein kinase (MAPK). We have reported that naofen, a novel WD40-repeat protein, may mediate apoptosis through caspase-3 activation. The present study was undertaken to investigate the potential involvement of naofen in diabetic angiopathy. Our results indicate that enhanced expression of naofen in vascular endothelial cells in kidney of streptozotocin-induced diabetic rats, also in high glucose-treated rat arterial endothelial cells. Furthermore, ROS generation, p38 MAPK activation and NF-κB activation, may be involved in high glucose-induced increase in naofen expression.

  • Research Products

    (11 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Enhanced expression of WD repeat-containing protein 35 (WDR35) stimulated by domoic acid in rat hippocampus: involvement of reactive oxygen species generation and p38 mitogen-activated protein kinase activation.2013

    • Author(s)
      Koji Tsunekawa, Fumio Kondo, Teruhiko Okada, Guo-Gang Feng, Lei Huang, Naohisa Ishikawa, Shoshiro Okada.
    • Journal Title

      BMC Neuroscience.

      Volume: 14(1) Pages: 4

    • DOI

      DOI:10.1186/1471-2202-14-4

    • Peer Reviewed
  • [Journal Article] Bupivacaine-induced apoptosis independently of WDR35 expression in mouse neuroblastoma Neuro2a cells.2012

    • Author(s)
      Misako Harato, Lei Huang, Fumio Kondo, Koji Tsunekawa, Guo-Gang Feng, Jun-Hua Fan, Naohisa Ishikawa, Yoshihiro Fujiwara, Shoshiro Okada.
    • Journal Title

      BMC Neuroscience.

      Volume: 13(1) Pages: 149

    • DOI

      DOI:10.1186/1471-2202-13-149

    • Peer Reviewed
  • [Journal Article] Effects of 1-O-hexyl-2,3,5-trimethylhydroquinone in Carbon Tetrachloride-induced Hepatic Apoptosis with a Possible Relationship to Naofen2012

    • Author(s)
      Koji Tsunekawa, Jun An, Lei Huang, Toshiaki Nonami, Tatsuro Koide, Fumio Kondo, Hiroshi Nishikawa, Tokutaro Miki, Satoru Sugiyama, Naohisa Ishikawa.
    • Journal Title

      International Journal of Pharmacology

      Volume: 8(5) Pages: 434-439

    • DOI

      DOI:10.3923/ijp.2012.434.439

    • Peer Reviewed
  • [Journal Article] Role of naofen in apoptosis of hepatocytes induced by lipopolysaccharide through mitochondrial signaling in rats.2012

    • Author(s)
      Jun-Hua Fan, Guo-Gang Feng, Lei Huang, Koji Tsunekawa, Takashi Honda, Yoshiaki Katano, Yoshiki Hirooka, Hidemi Goto, Nobuhisa Kandatsu, Kazuo Ando, Yoshihiro Fujiwara, Tatsuro Koide, Shoshiro Okada, Naohisa Ishikawa.
    • Journal Title

      Hepatology Research.

      Volume: 42(7) Pages: 696-705

    • DOI

      DOI:10.1111/j.1872-034X.2012.00972.x

    • Peer Reviewed
  • [Journal Article] Effects of Naofen on Enzyme Activities of Serine Proteases and Matrix Metallo-proteinases2011

    • Author(s)
      Orapin Wongsawatkul, Guo-Gang Feng, Chang Li, Lei Huang, Fumio Kondo, Shuji Kurokawa, Yoshihiro Fujiwara and Naohisa Ishikawa
    • Journal Title

      International Journal of Pharmacology

      Volume: 7(3) Pages: 388-393

    • DOI

      DOI:10.3923/ijp.2011.388.393

    • Peer Reviewed
  • [Presentation] Bupivacaine処理Neuro2a細胞におけるWDR35の発現に対するNF-κBの関与2013

    • Author(s)
      黄磊
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-03-21
  • [Presentation] LPSを投与したラット肝細胞のアポトーシスに対するプロポフォールの保護作用2013

    • Author(s)
      馮国剛、黄磊
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡市
    • Year and Date
      2013-03-21
  • [Presentation] BupivacaineはNeuro2a細胞におけるnaofen(WDR35)発現を増加させる----ROSを介するp38MAPK活性化との関連について2012

    • Author(s)
      黄磊
    • Organizer
      第21回日本CellDeath学会学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2012-07-27
  • [Presentation] ブピバカインはNeuro2a細胞におけるnaofen発現を増加させる2012

    • Author(s)
      黄磊
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都市
    • Year and Date
      2012-03-16
  • [Presentation] ドウモイ酸投与ラットの海馬における新規生体内物質Naofenの役割2012

    • Author(s)
      恒川幸司、黄磊
    • Organizer
      第85回日本薬理学会年会
    • Place of Presentation
      京都市
    • Year and Date
      2012-03-16
  • [Remarks]

    • URL

      http://www.aichi-med-u.ac.jp/su06/su0607/su060702/04.html#FS01

URL: 

Published: 2014-09-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi