2012 Fiscal Year Final Research Report
Role of naofen, a novel WD 40-repeat protein, in diabetic angiopathy
| Project/Area Number |
23790885
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Aichi Medical University |
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Principal Investigator |
HUANG Lei 愛知医科大学, 医学部, 助教 (00556095)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 糖尿病 / 血管障害 / 酸化ストレス / p38 MAPK |
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| Research Abstract |
High glucose was shown to elicit reactive oxygen species (ROS) production and induce apoptosis accompanied by activation of p38 mitogen-activated protein kinase (MAPK). We have reported that naofen, a novel WD40-repeat protein, may mediate apoptosis through caspase-3 activation. The present study was undertaken to investigate the potential involvement of naofen in diabetic angiopathy. Our results indicate that enhanced expression of naofen in vascular endothelial cells in kidney of streptozotocin-induced diabetic rats, also in high glucose-treated rat arterial endothelial cells. Furthermore, ROS generation, p38 MAPK activation and NF-κB activation, may be involved in high glucose-induced increase in naofen expression.
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Research Products
(11 results)
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[Journal Article] Effects of 1-O-hexyl-2,3,5-trimethylhydroquinone in Carbon Tetrachloride-induced Hepatic Apoptosis with a Possible Relationship to Naofen2012
Author(s)
Koji Tsunekawa, Jun An, Lei Huang, Toshiaki Nonami, Tatsuro Koide, Fumio Kondo, Hiroshi Nishikawa, Tokutaro Miki, Satoru Sugiyama, Naohisa Ishikawa.
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Journal Title
International Journal of Pharmacology
Volume: 8(5)
Pages: 434-439
DOI
Peer Reviewed
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[Journal Article] Role of naofen in apoptosis of hepatocytes induced by lipopolysaccharide through mitochondrial signaling in rats.2012
Author(s)
Jun-Hua Fan, Guo-Gang Feng, Lei Huang, Koji Tsunekawa, Takashi Honda, Yoshiaki Katano, Yoshiki Hirooka, Hidemi Goto, Nobuhisa Kandatsu, Kazuo Ando, Yoshihiro Fujiwara, Tatsuro Koide, Shoshiro Okada, Naohisa Ishikawa.
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Journal Title
Hepatology Research.
Volume: 42(7)
Pages: 696-705
DOI
Peer Reviewed
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