2012 Fiscal Year Final Research Report
Why EGFR-mutant positive cancer preferentially arise from lung?
| Project/Area Number |
23790892
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所) (2012)
Tohoku University (2011) |
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Principal Investigator |
FUKUHARA Tatsuro 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん先進治療開発研究部, 特任研究員 (80400365)
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| Project Period (FY) |
2011 – 2012
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| Keywords | EGFR変異陽性肺癌 |
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| Research Abstract |
To clear the direct role of mutant epidermal growth factor receptor(EGFR) in tumorigenesis, wild and mutant EGFR expressing cells were established using leukemic K562 cell line expressing no endogenous EGFR. These cell lines showed gefitinib-sensitivity, however, the EGFR T790M mutants expressing cells were gefitinib resistant. These results suggest that cells with wild or mutant EGFR are suitable for identification of oncogenic mechanism and mutant EGFR-induced addiction.
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Research Products
(2 results)
