Clarification of physiological function of lysophosphatidic acid in maintenance of lung stem cells and application for respiratory diseases.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790895
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Tohoku University
• Principal Investigator: KANEHIRA Masahiko 東北大学, 大学院・医学系研究科, 非常勤講 師 (90374941)
• Project Period (FY): 2011 – 2012
• Keywords: 肺幹細胞 / リゾリン脂質 / 細胞老化

Research Abstract

I tried to determine the relationship between lysophosphatidic acid (LPA) signaling and maintenance of stemness in lung stem cells. In lung SP cells, inhibition of LPA signaling significantly inhibited SA- -gal activity compared to control.

Research Products

• [Journal Article] Targeting lysophosphatidic acid signaling retards culture-associated senescence of human marrow stromal cells (2012)
  • Author(s): Kanehira, M., Kikuchi, T., Ohkouchi, S., Shibahara, T., Tode, N.,Santoso, A., Daito, H., Ohta, H., Tamada, T., Nukiwa, T
  • Journal Title: PLoS ONE Volume: 7 Pages: e32185
  • DOI: doi:10.1371/journal.pone.0032185
  • Peer Reviewed
• [Journal Article] Mesenchymal stromal cell (MSC) derived Stanniocalcin-1 promotes survival of injured lung cancer epithelial cells by upregulation of Uncoupling protein (2011)
  • Author(s): Ohkouchi, S., Block, GJ., Katsha, AM., Kanehira, M., Ebina, M., Kikuchi, T., Saijo, Y., Nukiwa, T.
  • Journal Title: Prockop.,DJ. Mol Ther Volume: 20 Pages: 417-423
  • DOI: doi:10.1038/mt.2011.259
  • Peer Reviewed
• [Journal Article] Mesenchymal Stromal Cells Promote Tumor Growth Through the Enhancement of Neovascularization (2011)
  • Author(s): Suzuki, K., Sun, R., Origuchi, M., Kanehira, M., Takahata,T., Itoh, J., Umezawa, A., Kijima, H., Fukuda, S., Saijo, Y.
  • Journal Title: Mol Med Volume: 17 Pages: 579-587
  • DOI: doi:10.2119/molmed.2010.00157
  • Peer Reviewed
• [Patent(Industrial Property Rights)] リゾリン脂質シグナル制御による幹 細胞の維持増殖培養法 (2012)
  • Inventor(s): 菊地利明、兼 平雅彦 、貫和敏博
  • Industrial Property Rights Holder: 菊地利明、兼 平雅彦 、貫和敏博
  • Industrial Property Number: 特許、特願 2012-001441
  • Filing Date: 2012-01-06
• [Patent(Industrial Property Rights)] リゾリン脂質シグナル制御による幹細胞の維持増殖培養法 (2012)
  • Inventor(s): 菊地利明、兼平雅彦 、貫和敏博
  • Industrial Property Rights Holder: 菊地利明、兼平雅彦 、貫和敏博
  • Industrial Property Number: 特許、特願PCT/JP2012/82979
  • Filing Date: 2012-01-06
  • Overseas