2012 Fiscal Year Final Research Report
Akt kinase-interacting protein1, a novel therapeutic target for lung cancer with EGFR-activating and gatekeeper mutations
| Project/Area Number |
23790902
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 肺癌 / 分子標的治療 / EGFR変異 |
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| Research Abstract |
We focused on Akt kinase-interacting protein1 (Aki1), a scaffold protein of PI3K /PDK1/Akt, and assessed its role in EGFR mutant lung cancer. Aki1 constitutively associates with mutant EGFR in lung cancer cells. Silencing of Aki1 inhibited cell growth of EGFR mutant lung cancer cells and induced apoptosis of them. Treatment with Aki1 siRNA dramatically inhibited growth of EGFR mutant lung cancer cells in a xenograft model. Moreover, Aki1 was frequently expressed in tumor cells of EGFR mutant lung cancer patients, including those with acquired resistance to EGFR-TKI treatment. Our data suggest that Aki1 may be an ideal target for EGFR mutant lung cancer patients, especially those with acquired EGFR-TKI resistance due to EGFR T790M gatekeeper mutation.
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[Journal Article] Akt kinase-interacting protein1, a novel therapeutic target for lung cancer with EGFR activating and gatekeeper mutations.2012
Author(s)
Yamada T, Takeuchi S, Fujita N, Nakamura A, Wang W, Li Q, Oda M, Mitsudomi T, Yatabe Y, Sekido Y, Yoshida J, Higashiyama M, Noguchi M, Uehara H, Nishioka Y, Sone S, Yano S.
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Journal Title
Oncogene
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] EGFR ligands, Amphiregulin and Heparin-binding EGF-like Growth Factor Promote Peritoneal Carcinomatosis in CXCR4-expressing Gastric Cancer.2011
Author(s)
Yasumoto K, Yamada T, Kawashima A, Wang W , Li Q, Donev IS, Tacheuchi S, Mouri H, Yamashita K, Ohtsubo K, Yano S.
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Journal Title
Clin Cancer Res
Volume: 17
Pages: 3619-3630
DOI
Peer Reviewed
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