Analysis of circulating genetically abnormal cells in lung cancer patients

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790908
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: 独立行政法人国立がん研究センター (2012); Tottori University (2011)
• Principal Investigator: MATSUMOTO Shingo 独立行政法人国立がん研究センター, 臨床開発センター, 医師 (10392341)
• Project Period (FY): 2011 – 2012
• Keywords: 肺癌 / 末梢血癌細胞 / ゲノム異常 / 遺伝子変異 / バイオマーカー

Research Abstract

Personalized medicine based on appropriate molecular biomarkers is hoped to improve prognoses of lung cancer patients. Biomarker analyses with circulating tumor cells or cell-free DNA (i.e., liquid biopsy) are quick, simple and non-invasive for advanced lung cancer patients. I established a rapidly and simultaneously detecting system of multiple genetic alterations from limited amounts of samples for efficiently selecting therapeutic populations.

Research Products

• [Journal Article] Identification of a lung adenocarcinoma cell line with CCDC6-RET fusion gene and the effect of RET inhibitors in vitro and in vivo.
  • Author(s): Suzuki M, Makinoshima H, Matsumoto S, Suzuki A, Mimaki S, Matsushima K, Yoh K, Goto K, Suzuki Y, Ishii G, Ochiai A, Tsuta K, Shibata T, Kohno T, Esumi H, Tsuchihara K
  • Journal Title: Cancer Sci Volume: (in press)
  • Peer Reviewed
• [Presentation] Establishment of a diagnostic system using next generation sequencing for RET rearrangements in non-small cell lung cancer (2013)
  • Author(s): Matsumoto S, Mimaki S, Tada S, Suzuki Y, Kohno T, Tsuta K, Goto K, Yoh K, Umemura S, Niho S, Ohmatsu H, Ohe Y, Esumi H and Tsuchihara K
  • Organizer: European Cancer Congress 2013
  • Place of Presentation: Amsterdam, Nederland
  • Year and Date: 20130900