2012 Fiscal Year Final Research Report
Study of inhaled nanoparticles incorporating synthetic oligodeoxynucleotides to treat lung diseases
| Project/Area Number |
23790917
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
SATO Takashi 横浜市立大学, 附属病院, 助教 (70510436)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 免疫調節性 DNA / ナノ粒子 |
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| Research Abstract |
We have developed biodegradable polyketal nano-particles containing immune-modulatory oligodeoxynucleotides (PKN-ODN), that degraded as predicted under physiologic conditions. To evaluate the ability of PKN-ODN to reduce pulmonary inflammation, well established silicosis and elastase-induced emphysema mouse models were used to develop the technology for the endotracheal delivery of PKN-ODN designed for the treatment pulmonary inflammation and the subsequent monitoring of the outcome of such intervention by Flexivent pulmonary function measuring system. In murine emphysema model, single intratracheal instillation of immune-stimulatory ODN could improve the changes in lung function parameters (Resistance, Elastance, Compliance), implying a potential treatment option.
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