2012 Fiscal Year Final Research Report
The details and physiologic significance of human renal proximal tubule specific stimulation of Na transport by Angiotensin II
| Project/Area Number |
23790932
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
HORITA Shoko 東京大学, 医学部附属病院, 助教 (20534895)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 高血圧学 |
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| Research Abstract |
AngII has biphasic effect (stimulation in low concentration and inhibition in high concentration) on mouse proximal tubule (PT) but in human AngII monophasically stimulates PT transport. To clarify this, NBCe1 activity in PT was measured in human, wild-type and cGKII-/- mice kidney. In human inhibition of NO blocked AngII effect, meanwhile NO donor stimulated NBCe1 activity via ERK. In wild-type mice the inhibition by high concentration of AngII changed to stimulation by inhibition of NO, while NO donor suppressed NBCe1. It was suggested that in human PT AngII has monophasic stimulatory effect via NO and consequent ERK activation, and regulation of blood pressure by AngII is more important.
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[Journal Article] Thiazolidinediones enhance sodium- coupled bicarbonate absorption from renal proximal tubules via PPAR γ -dependent nongenomic signaling2011
Author(s)
Yamazaki O, Shirai A, Nakamura M, Iso-O N, Li Y, Hara M, Tsukamoto K, Yamauchi T, Kubota N, Kadowaki T, Seki G
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Journal Title
Cell Metabolism
Volume: 13(5)
Pages: 550-61
DOI
Peer Reviewed
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[Journal Article] Severe metabolic acidosis causes early lethality in NBC1 W516X knock-in mice as a model of human isolated proximal renal tubular acidosis2011
Author(s)
Lo YF, Yang SS, Seki G, Yamada H, Horita S, Yamazaki O, Fujita T, Usui T, Tsai JD, Yu IS, Lin SW, Lin SH.
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Journal Title
Kidney International
Volume: 79(7)
Pages: 730-41
DOI
Peer Reviewed
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