2012 Fiscal Year Final Research Report
Histopathological prognostic factors of IgA nephropathy
| Project/Area Number |
23790940
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | IgA 腎症 / 腎細動脈硝子化 |
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| Research Abstract |
In patients with IgA nephropathy, one of the major causes of end-stage kidney disease in Japan, little information is available about the factors which affect the histopathological vascular lesion except for hypertension. The present study identified age (especially >=25 years), hypertension (especially mean arterial pressure >=92mmHg) and hyperuricemia. These results strongly suggest that hyperuricemia may induce hypertensive vascular lesions, partially leading to progression of IgA nephropathy
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