2013 Fiscal Year Final Research Report
Mechanisms of blood pressure regulation by renal GABAergic system
| Project/Area Number |
23790949
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
YATABE Junichi 福島県立医科大学, 医学部, 助教 (10566681)
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| Project Period (FY) |
2011 – 2013
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| Keywords | GABA / 高血圧 / 腎臓 / 食塩 / 尿細管 |
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| Research Abstract |
Gamma-aminobutyric acid (GABA) is an important neurotransmitter, but recent reports have revealed the expression of GABAergic components in peripheral, non-neural tissues. GABA administration induces natriuresis and lowers blood pressure, suggesting renal GABA targets. However, systematic evaluation of renal GABAergic components has not been reported. In this study, rat kidney was used to see expressions of GABA-related molecules. GABAA receptor subunits, alpha1, beta3 and pi, both types of GABAB receptors, R1 and R2, and GABAC receptor rho1 and rho2 subunit expressions were detected. GABA producing enzymes, its transporters and degrading enzyme were also expressed. In vivo study, GAD67 hetero knockout mice showed paradoxically showed a reduced blood pressure compared to wild-type mice.
In summary, unique set of GABA related molecules and functions were found in rat kidney cortex. A possible existence of local renal GABAergic system is suggested.
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