Prevention of recurrence after high dose chemotherapy with autologous stem-cell transplantation in Crow-Fukase syndrome

2012 Fiscal Year Final Research Report

• Project/Area Number: 23790975
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Chiba University
• Principal Investigator: MISAWA Sonoko 千葉大学, 大学院・医学研究院, 助教 (30375753)
• Project Period (FY): 2011 – 2012
• Keywords: クロウ / 深瀬症候群 / サリドマイド / 移植後再発 / 臨床試験

Research Abstract

Crow-Fukase syndrome is a rare multisystemic disorder characterized by polyneuropathy, effusion, renal dysfunction, and skin change. To investigate risk factors of recurrence after high dose chemotherapy with autologous stem-cell transplantation (HCT with ASCT), we studied clinical and laboratory profiles of 24 patients who underwent HCT with ASCT. Induction therapies prior to transplantation and lower VEGF levels were associated with lower risk for recurrence. Based on those findings we are planning a clinical trial to explore the efficacy of thalidomide as an induction therapy before transplantation.

Research Products

• [Journal Article] Ambiguous effects of anti-VEGF monoclonal antibody (bevacizumab) for POEMS syndrome (2013)
  • Author(s): Sekiguchi Y, Misawa S, Shibuya K, Nasu S, Mitsuma S, Iwai Y, Beppu M, Sawai S, Ito S, Hirano S, Nakaseko C, Kuwabara S.
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: (in press)
  • Peer Reviewed
• [Journal Article] Multiple angiogenetic factors are upregulated in POEMS syndrome (2013)
  • Author(s): Yamada Y, Sawai S, Misawa S, Kanai K, Shibuya K, Mori M, Moriya J, Sogawa K, Yamamoto H, Beppu M, Taniguchi J, Nakaseko C, Nomura F, Kuwabara S.
  • Journal Title: Ann Hematol Volume: Vol92No2 Pages: 245-248
  • DOI: doi:10.1007/s00277-012-1583-2.
  • Peer Reviewed
• [Journal Article] Markedly upregulated serum interleukin-12 asa novel biomarker in POEMS syndrome (2012)
  • Author(s): Kanai K, Sawai S, Sogawa K, Mori M, Misawa S, Shibuya K, Isose S, Fujimaki Y, Noto Y, Sekiguchi Y, Nasu S, Nakaseko C, Takano S, Yoshitomi H, Miyazaki M, Nomura F, Kuwabara S.
  • Journal Title: Neurology Volume: Vol.79,No.6 Pages: 575-582
  • DOI: doi:10.1212/WNL.0b013e318263c42b.
  • Peer Reviewed
• [Journal Article] Treatment for POEMS (polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes) syndrome (2012)
  • Author(s): Kuwabara S, Dispenzieri A, Arimura K, Misawa S, Nakaseko C.
  • Journal Title: Cochrane Database Syst Rev Volume: Vol.6 Pages: CD006828
  • DOI: doi:10.1002/14651858.CD006828.pub3.
  • Peer Reviewed
• [Journal Article] Mobilization of PBSCs in poor mobilizers with POEMS syndrome using G-CSF with plerixafor (2012)
  • Author(s): Shimizu N, Sakaida E, Ohwada C, Takeuchi M, Kawaguchi T, Tsukamoto S, Sakai S, Takeda Y, Sugita Y, Yokote K, Iseki T, Isose S, Kanai K, Misawa S, Kuwabara S, Nakaseko C.
  • Journal Title: Bone Marrow Transplant Volume: Vol.47,No.12 Pages: 1587-8
  • DOI: doi:10.1038/bmt.2012.80.
  • Peer Reviewed
• [Journal Article] Preserved autonomic function in patients with POEMS syndrome (2012)
  • Author(s): Fujinuma Y, Asahina M, Fukushima T, Katagiri A, Yamanaka Y, Misawa S, Kuwabara S.
  • Journal Title: J Neurol Sci Volume: Vol.318,No.1-2 Pages: 131-4
  • DOI: doi:10.1016/j.jns.2012.03.004.
  • Peer Reviewed
• [Journal Article] Different neurological and physiological profiles in POEMS syndrome and chronic inflammatory demyelinating polyneuropathy (2012)
  • Author(s): Nasu S, Misawa S, Sekiguchi Y, Shibuya K, Kanai K, Fujimaki Y, Ohmori S, Mitsuma S, Koga S, Kuwabara S.
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: Vol.83,No.5 Pages: 476-9
  • DOI: doi:10.1136/jnnp-2011-301706.
  • Peer Reviewed
• [Journal Article] Factors associated with the efficiency of PBSC collection in POEMS syndrome patients undergoing autologous PBSC transplantation (2012)
  • Author(s): Shimizu N, Nakaseko C, Sakaida E, Ohwada C, Takeuchi M, Kawaguchi T, Tsukamoto S, Sakai S, Takeda Y, Abe D, Yokote K, Iseki T, Kanai K, Misawa S, Kuwabara S.
  • Journal Title: Bone Marrow Transplant Volume: Vol.47,No.7 Pages: 1010-1012
  • DOI: doi:10.1038/bmt.2011.211.
  • Peer Reviewed
• [Journal Article] Detection of bone lesions by CT in POEMS syndrome (2011)
  • Author(s): Shibuya K, Misawa S, Horikoshi T, Kanai K, Isose S, Nasu S, Sekiguchi Y, Noto Y, Fujimaki Y, Nakaseko C, Kuwabara S.
  • Journal Title: Intern Med Volume: Vol.50,No.13 Pages: 1393-1396
  • Peer Reviewed
• [Journal Article] POEMS syndrome with Guillan-Barre syndrome-like acute onset: acase report and review of neurological progression in 30 cases (2011)
  • Author(s): Isose S, Misawa S, Kanai K, Shibuya K, Sekiguchi Y, Nasu S, Fujimaki Y, Noto Y, Nakaseko C, Kuwabara S.
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: Vol.82,No.6 Pages: 678-680
  • DOI: doi:10.1136/jnnp.2010.205369.
  • Peer Reviewed
• [Presentation] POEMS症候群に対して抗VEGFモノクローナル抗体療法は有効か? (2012)
  • Author(s): 関口縁、三澤園子、澁谷和幹、那須彩子、三津間さつき、岩井雄太、磯瀬沙希里、桑原聡
  • Organizer: 第30回日本神経治療学会
  • Place of Presentation: 福岡県
  • Year and Date: 20121128-20121130
• [Presentation] POEMS症候群とCIDPの軸索特性の比較:軸索機能検査法を用いた検討 (2012)
  • Author(s): 三津間さつき、三澤園子、澁谷和幹、磯瀬沙希里、那須彩子、関口縁、岩井雄太、大森茂樹、杉本一男
  • Organizer: 第42回日本臨床神経生理学会
  • Place of Presentation: 東京都
  • Year and Date: 20121108-20121110
• [Presentation] POEMS症候群の自己末梢血幹細胞移植後の再発に関与する因子の検討 (2012)
  • Author(s): 三澤園子、澁谷和幹、関口縁、那須彩子、三津間さつき、岩井雄太、桑原聡
  • Organizer: 第24回日本神経免疫学会学術集会
  • Place of Presentation: 長野県
  • Year and Date: 20120920-20120921
• [Presentation] POEMS症候群におけるVEGFの意義:抗VEGFモノクローナル抗体の有効性の観点から (2012)
  • Author(s): 関口縁、三澤園子、澁谷和幹、那須彩子、三津間さつき、岩井雄太、桑原聡
  • Organizer: 第24回日本神経免疫学会学術集会
  • Place of Presentation: 長野県
  • Year and Date: 20120920-20120921
• [Presentation] POEMS症候群とCIDPの臨床像の比較:鑑別に有用な所見は何か? (2012)
  • Author(s): 那須彩子、三澤園子、澁谷和幹、関口縁、三津間さつき、岩井雄太、桑原聡
  • Organizer: 第24回日本神経免疫学会学術集会
  • Place of Presentation: 長野県
  • Year and Date: 20120920-20120921
• [Presentation] POEMS症候群とCIDPの脱髄のメカニズムの比較:軸索機能検査法による検討 (2012)
  • Author(s): 三津間さつき、三澤園子、澁谷和幹、磯瀬沙希里、那須彩子、関口縁、金井数明、桑原聡
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京都
  • Year and Date: 20120522-20120525
• [Presentation] POEMS症候群におけるサリドマイド療法:中・長期効果を中心に (2012)
  • Author(s): 三澤園子、澁谷和幹、金井数明、磯瀬沙希里、関口縁、那須彩子、別府美奈子、三津間さつき、桑原聡
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京都
  • Year and Date: 20120522-20120525
• [Presentation] POEMS症候群の新規治療の現状と今後の課題 (2012)
  • Author(s): 三澤園子
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京都
  • Year and Date: 20120522-20120525
• [Presentation] POEMS症候群に対する新規治療の現状:末梢血幹細胞移植とサリドマイド療法 (2012)
  • Author(s): 三澤園子、中世古知昭、澁谷和幹、金井数明、武内正博、大和田千桂子、清水直美、桑原聡
  • Organizer: 第109回日本内科学会
  • Place of Presentation: 京都府
  • Year and Date: 2012-05-12