2012 Fiscal Year Final Research Report
Identification of immune target for acute inflammatory demyelinating polyneuropathy by proteomic analysis
| Project/Area Number |
23790976
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Chiba University |
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Principal Investigator |
SAWAI Setsu 千葉大学, 大学院・医学研究院, 助教 (10400962)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ギラン / バレー症候群 / プロテオーム解析 / 神経免疫学 |
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| Research Abstract |
By using proteomic analysis, we searched for the immune target of Acute Inflammatory Demyelinating Polyneuropathy (AIDP). The target was considered to be the protein on the surface of the Schwann cell. We extract proteins from Schwannoma cell line, and we searched for the protein which reacted with the antibody (IgG) of the patients by 2 dimensional electrophoresis and western blotting. The proteins were identified with mass spectrometer. Among 22 patients, 7 had autoantibody for this protein, but normal controls and patients with axonal type of GBS rarely had. It may suggest this protein is specific immune target of AIDP.
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[Journal Article] Pentanucleotide repeat-primed PCR for genetic diagnosis of spinocerebellar ataxia type 312012
Author(s)
Ishige T, Sawai S, Itoga S, Sato K, Utsuno E, Beppu M, Kanai K, Nishimura M, Matsushita K, Kuwabara S, Nomura F.
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Journal Title
J Hum Genet
Volume: 57(12)
Pages: 807-8
DOI
Peer Reviewed
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[Journal Article] Markedly upregulated serum interleukin-12 as a novel biomarker in POEMS syndrome2012
Author(s)
Kanai K, Sawai S, Sogawa K, Mori M, Misawa S, Shibuya K, Isose S, Fujimaki Y, Noto Y, Sekiguchi Y, Nasu S, Nakaseko C, Takano S, Yoshitomi H, Miyazaki M, Nomura F, Kuwabara S.
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Journal Title
Neurology
Volume: 79(6)
Pages: 575-82
DOI
Peer Reviewed
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[Journal Article] Proteomic analysis of gingival crevicularfluid for discovery of novel periodontaldisease markers2012
Author(s)
Tsuchida S, Satoh M, Umemura H, SogawaK, Kawashima Y, Kado S, Sawai S, Nishimura M, Kodera Y, Matsushita K, Nomura F.
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Journal Title
Proteomics
Volume: 12(13)
Pages: 2190-202
DOI
Peer Reviewed
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[Journal Article] Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: specificity,sensitivity, and a possible prognosticvalue2011
Author(s)
Noto Y, Shibuya K, Sato Y, Kanai K,Misawa S, Sawai S, Mori M, Uchiyama T,Isose S, Nasu S, Sekiguchi Y, Fujimaki Y,Kasai T, Tokuda T, Nakagawa M, Kuwabara S.
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Journal Title
Amyotroph Lateral Scler
Volume: 12(2)
Pages: 140-3
DOI
Peer Reviewed
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[Journal Article] Altered axonal excitability properties injuvenile muscular atrophy of distal upperextremity (Hirayama disease)2011
Author(s)
Sawai S, Misawa S, Kanai K, Isose S,Shibuya K, Noto Y, Fujimaki Y, SekiguchiY, Nasu S, Nomura F, Kuwabara S.
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Journal Title
ClinNeurophysiol
Volume: 122(1)
Pages: 205-9
DOI
Peer Reviewed
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