2012 Fiscal Year Final Research Report
Analysis of Teneurin-4 Function in the CNS Myelination
| Project/Area Number |
23790979
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SUZUKI Nobuharu 東京医科歯科大学, 大学院・保健衛生学研究科, 講師 (30596565)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経分子病態学 |
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| Research Abstract |
In this study, we focused on function of the transmembrane protein teneurin-4 (Ten-4). In the Ten-4 deficient mice, hypomyelination of small-diameter axons was observed. The process formation of Ten-4 deficient oligodendrocytes was significantly reduced. Further, focal adhesion kinase (FAK) played a role downstream of Ten-4 in the process formation. This study will facilitate a better understanding of oligodendrocyte biology and be useful for application studies for the myelin-related diseases.
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