2012 Fiscal Year Final Research Report
Enhanced arteriogenesis for prevention of ischemic brain damage
| Project/Area Number |
23790980
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
ISHIBASHI Satoru 東京医科歯科大学, 医学部附属病院, 助教 (30533369)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 脳梗塞 / 動物モデル / 動脈新生 / 慢性低灌流 / ずり応力 / FGF-2 |
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| Research Abstract |
Positive outward remodeling of pre-existing of De-novo collateral arteries into functional conductance arteries, arteriogenesis, is a major endogenous rescue mechanism to prevent ischemic damage after stroke. We, here, investigated the mechanism of arteriogenesis or examined effect on ischemia brain damage by means of promoting arteriogenesis with basic fibroblast growth factor 2 (FGF-2) in experimental chronic brain hypoperfused mice model.Brain hypoperfusion significantly increased the diameter of leptomeningeal arteries,and the number of proliferating endothelial or smooth muscle cells in the arteries. Hypoperfused or sham animals underwent subsequent ipsilateral middle cerebral artery occlusion, and infarct volume was assessed. The total infarction volume was significantly decreased in hypoperfused mice than sham-operated animals. FGF-2 administration enhanced collateral artery growth and further reduced infarction volume, resulting in long-term functional recovery.
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[Journal Article] Transplantation of human neural stem/progenitor cells overexpressing galectin-1 improves functional recovery from focal brain ischemia in the mongolian gerbil.2011
Author(s)
Yamane J, Ishibashi S, Sakaguchi M, Kuroiwa T, Kanemura Y, Nakamura M, Miyoshi H, Sawamoto K, Toyama Y, Mizusawa H, Okano H.
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Journal Title
Mol Brain.
Volume: 4
Pages: 35
Peer Reviewed
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