2013 Fiscal Year Final Research Report
Molecualr therapy and imaging for neurodegenerative disease with tissue specific targeting peptides
| Project/Area Number |
23790988
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Hideto 滋賀医科大学, 医学部, 教授 (00225434)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 分子治療 / 遺伝子治療 / イメージング / 組織特異的ペプチド / 標的化 |
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| Research Abstract |
Engineering the new strategy of imaging or molecular therapy for spinal cord, we investigated to identify the specific peptides to bind with spinal cord. At last, we identified two kinds of peptides, which had high affinity with spinal cord. Next, we tried the examination for the imaging of spinal cord with using the peptides. Unfortunately, we couldn't success to establish the new imaging method with the peptides because the sensitivities had some problems. However, we succeeded the targeting to spinal cord with the peptides, which could effectively deliver the small oligonucleotides to spinal cord. This strategy has high potential to realize the new molecular therapy for non-curable neurological disease, which is expected to be arranged to more suitable condition for the neurodegenerative diseases.
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[Journal Article] Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy2014
Author(s)
Katagi M, Terashima T, Okano J, Urabe H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H
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Journal Title
Peer Reviewed
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[Journal Article] Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus2013
Author(s)
Urabe H, Kojima H, Chan L, Terashima T, Ogawa N, Katagi M, Fujino K, Kumagai A, Kawai H, Asakawa A, Inui A, Yasuda H, Eguchi Y, Oka K, Maegawa H, Kashiwagi A, Kimura H
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Journal Title
Nat. Commun
Volume: 4
Pages: 1526
Peer Reviewed
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[Journal Article] Interleukin-7 induces recruitment of monocytes/macrophages to endothelium2012
Author(s)
Li R, Paul A, Ko KW, Sheldon M, Rich BE, Terashima T, Dieker C, Cormier S, Li L, Nour EA, Chan L, Oka K
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Journal Title
Eur. Heart J
Volume: 33(24)
Pages: 3114-23
Peer Reviewed
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[Journal Article] Brain-Derived Neurotrophic Factor from Bone Marrow-Derived Cells Promotes Post-Injury Repair of Peripheral Nerve2012
Author(s)
Takemura Y, Imai S, Kojima H, Katagi M, Yamakawa I, Kasahara T, Urabe H, Terashima T, Yasuda H, Chan L, Kimura H, Matsusue Y
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Journal Title
PLoS One
Volume: 7 (9)
Pages: e44592
Peer Reviewed
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[Journal Article] Inactivation of TNF-αameliorates diabetic neuropathy in mice2011
Author(s)
Yamakawa I, Kojima H, Terashima T, Katagi M, Oi J, Urabe H, Sanada M, Kawai H, Chan L, Yasuda H, Maegawa H, Kimura H
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 301(5)
Pages: E844-52
Peer Reviewed
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[Presentation] ENGINIEERING OF GENE THERAPY FOR NEUROPATHIC PAIN BY SILENCING OF TNFαIN DRG FROM SPINAL NERVE TRANSECTION MODEL MOUSE2012
Author(s)
Nobuhiro Ogawa, Tomoya Terashima, Kazuhiro Oka, Hideto Kojima, Fumiko Hayase, Jiro Oi, Isamu Yamakawa, Hyoh Kim, Lawrence Chan, Hiromichi Kawai, Hiroshi Maegawa
Organizer
Japan Society of Gene Therapy
Year and Date
20120600
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