2012 Fiscal Year Final Research Report
A pathological study of impaired cytoplasmic-nuclear transport impairment infamilial ALS patients harboring FUS mutatio
| Project/Area Number |
23790997
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 筋萎縮性側索硬化症 / FUS / 神経化学 / サイトカイン / ケモカイン / 神経病理学 |
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| Research Abstract |
We first showed that in the spinal motor neurons of familial and sporadic amyotrophic lateral sclerosis (ALS) patients, cytoplasmic-nuclear transport of transcriptional mediators were impaired. We analyzed on this issue using SOD1-trangenic mouse, and revealed that these pathological findings were detectable prior to motor neuron degeneration
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[Journal Article] Impared Cytoplasmic-Nuclear Transport of Hypoxia-inducible Factor-1 αin Amyotrophic Lateral Sclerosis2013
Author(s)
Nagara Y, Tateishi T, Yamasaki R, Hayashi S, Kawamura M, Kikuchi H, Iinuma KM, Tanaka M, Iwaki T, Matsushita T, Ohyagi Y, Kira JI.
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Inflammatory radiculopathy in an ALS4 patient with a novel SETX mutation.2012
Author(s)
Saiga T, Tateishi T, Torii T, Kawamura N, Nagara Y, Shigeto H, Hashiguchi A, Takashima H, Honda H, Ohyagi Y, Kira J.
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: 83(7)
Pages: 763-4
DOI
Peer Reviewed
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