2012 Fiscal Year Final Research Report
Role of cellular senescence factor Ecrg4-investigating its expression and identifying its receptor which may be a therapeutic target in Alzheimer's Disease
| Project/Area Number |
23791001
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
KUJURO Yuki 慶應義塾大学, 医学部, 助教 (60398625)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞老化 / アルツハイマー病 / 受容体 / 分泌因子 / 認知症 |
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| Research Abstract |
In the brains of ApoE4 Alzheimer’s Disease transgenic mice, SA-β-gal activity and expression of Ecrg4 was elevated compared to non transgenic mice. Our data suggests that cellular senescence might be one of the causal mechanisms of Alzheimer’s Disease. By
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