2012 Fiscal Year Final Research Report
Investigation of cellular toxicity induced by LIN28 in amyotrophic lateral sclerosis
| Project/Area Number |
23791002
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
|
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Keywords | 筋萎縮性側索硬化症 (ALS) / TDP-43 / 胚性幹細胞 (ES 細胞) / 運動神経細胞死 |
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| Research Abstract |
We established the procedures of transfection into human motor neurons derived from embryonic stem (ES) cells, of which magnetofection was proved most useful. Taking advantage of this procedure, 26k-Da C terminal isoform and mutant forms of TDP-43, that i
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