2013 Fiscal Year Final Research Report
RNA metabolism and RNA-binding proteins in polyglutamine diseases
| Project/Area Number |
23791007
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KINO Yoshihiro 独立行政法人理化学研究所, 脳科学総合研究センター, 客員研究員 (80415140)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経変性疾患 / ポリグルタミン |
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| Research Abstract |
Polyglutamine diseases, including Huntington's disease, are genetic disorders caused by a repeat expansion of CAG repeat tracts in protein-coding regions. This study revealed aberrant RNA processing in polyglutamine diseases using cultured cells and disease model mice, suggesting the involvement of RNA-binding proteins in the disease pathogenesis. In addition, RNA-binding proteins have a potential regulatory role in the expression of the gene products of a polyglutamine disease.
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