2012 Fiscal Year Final Research Report
Role of OGR1 family G protein-coupled receptors in mechanism of insulin secretion
| Project/Area Number |
23791014
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Teikyo University (2012)
Gunma University (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | エネルギー / 糖質代謝異常 |
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| Research Abstract |
OGR1 family receptors response to extracellular pH and lysolipid, however its functions in insulin secretion are unknown. In this study, we investigated glucose tolerance and insulin sensitivity in OGR1-deficient mice. Moreover, islets isolated from OGR1-deficient mice and INS-1 cells were analyzed for the mechanisms of insulin secretion by acidification of extracellular pH. These results indicated that OGR1 responded to extracellular pH andregulated the glucose-stimulated insulin secretion in the pancreatic beta cells.
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[Journal Article] Deficiency of Proton-Sensing Ovarian Cancer G Protein-Coupled Receptor 1 Attenuates Glucose-Stimulated Insulin Secretion2012
Author(s)
Nakakura T, Mogi C, Tobo M, TomuraH, Sato K, Kobayashi M, Ohnishi H, Tanaka S, Wayama M, Sugiyama T, Kitamura T, Harada A, Okajima F
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Journal Title
Endocrinology
Volume: 153
Pages: 4171-4180
DOI
Peer Reviewed
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