2012 Fiscal Year Final Research Report
Function of mitochondrial SIRT5 protein and metabolic interactionbetween liver and skeletal muscle
| Project/Area Number |
23791026
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Metabolomics
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | ミトコンドリア / 細胞 / 老化 / 肝臓 / マウス / サーチュイン / 核酸代謝 |
|---|
| Research Abstract |
We identified urate oxidase (UOX) as a target of SIRT5 by using two-dimensional electrophoresis. Acetylation levels of UOX in liver of SIRT5 Tg mice were approximately half of those in wild-type mice, and UOX activity was significantly increased.
|
