2012 Fiscal Year Final Research Report
Function of mitochondrial SIRT5 protein and metabolic interactionbetween liver and skeletal muscle
Project/Area Number |
23791026
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Metabolomics
|
Research Institution | Kyoto University |
Principal Investigator |
|
Project Period (FY) |
2011 – 2012
|
Keywords | ミトコンドリア / 細胞 / 老化 / 肝臓 / マウス / サーチュイン / 核酸代謝 |
Research Abstract |
We identified urate oxidase (UOX) as a target of SIRT5 by using two-dimensional electrophoresis. Acetylation levels of UOX in liver of SIRT5 Tg mice were approximately half of those in wild-type mice, and UOX activity was significantly increased.
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