2012 Fiscal Year Final Research Report
Role of cAMP response element binding (CREB) coactivator CRTC3 on adipogenesis
| Project/Area Number |
23791037
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Kumamoto University |
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Principal Investigator |
IGATA Motoyuki 熊本大学, 医学部附属病院, 特任助教 (40599099)
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| Project Period (FY) |
2011 – 2012
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| Keywords | メタボリックシンドローム |
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| Research Abstract |
It is known that cAMP-CREB signal has a role in adipocyte differentiation and lipolysis.We studied the role of CREB co-activator CRTC3 in adipocyte, especially on adipogenesis.In this project, we showed that adipocyte differentiation was inhibited by knockdown ofCRTC3 in 3T3L1 cells. In the promoter analysis of CRTC3 gene, CRTC3 promoter has a cAMPresponsive element (CRE) and is regulated positively by itself through the CRE.
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[Journal Article] Regulation of TNFαconverting enzyme activity in visceraladipose tissue of obese mice2013
Author(s)
Kawasaki S, Motoshima H, Hanatani S,Takaki Y, Igata M, Tsutsumi A, MatsumuraT, Kondo T, Senokuchi T, Ishii N, KinoshitaH , F uku da K, Kaw ash ima J, Shi mod a S ,Nishikawa T, Araki E
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Journal Title
Biochem Biophys Res Commun
Volume: 430
Pages: 1189-94
Peer Reviewed
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[Journal Article] Caroric restrictiondecreases ER stress in liver and adiposetissue in ob/ob mice2011
Author(s)
Tsutsumi A, Motoshima H, Kondo T,Kawasaki S, Matsumura T, Hanatani S, IgataM, Ishii N, Kinoshita H, Kawashima J,Taketa K, Furukawa N, Tsuruzoe K,Nishikawa T, Araki E
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Journal Title
Biochem Biophys ResCommun
Volume: 404
Pages: 339-344
Peer Reviewed
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