Identification and functional analysis of novel MR co-regulator

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791051
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Keio University
• Principal Investigator: YOKOTA Kenichi 慶應義塾大学, 医学部, 助教 (50424156)
• Project Period (FY): 2011 – 2012
• Keywords: アルドステロン / 転写

Research Abstract

We identified p150 as a novel MR co-regulator. P150 interacts with MR in a ligand dependent manner and acts as a co-repressor. It is possible that p150 plays an important role in the pathophysiology of essential hypertension.

Research Products

• [Journal Article] PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B (2011)
  • Author(s): Baba, F Ohtake, Y Okuno, K Yokota, M Okada, Y Imai, Ni M, CA Meyer, K Igarashi, J Kanno, M Brown, S Kato
  • Journal Title: Nature Cell Biology Volume: 13(6) Pages: 668-75
  • DOI: Doi:10.1038/ncb2228
  • Peer Reviewed
• [Journal Article] Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1. (2011)
  • Author(s): N Suda ,H Shibata, I Kurihara, Y Ikeda, S Kobayashi, K Yokota, A Murai-Takeda, K Nakagawa, M Oya, M Murai, WE Rainey, T Saruta, H Itoh.
  • Journal Title: Endocrinology. Volume: 152(6) Pages: 2266-77
  • DOI: Doi:10.1210/en.2010-1232
  • Peer Reviewed
• [Presentation] 新規MR転写共役因子の探索とその機能解析 (2011)
  • Author(s): 横田健一
  • Organizer: 2011 年日本ステロイドホルモン学会(福岡)にて招待講演
  • Place of Presentation: 福岡
  • Year and Date: 2011-11-26
• [Presentation] 新規MR転写共役因子の探索とその機能解析 (2011)
  • Author(s): 横田健一
  • Organizer: 2011年核内受容体研究会(東京)にて招待講演
  • Place of Presentation: 東京
  • Year and Date: 2011-03-11
• [Book] 副腎不全medicina49(9) (2012)
  • Author(s): 横田健一, 柴田洋孝
  • Total Pages: 1588-1592
• [Book] ミネラルコルチコイド受容体の活性化による心血管障害 原発性アルドステロン症診療マニュアル (2011)
  • Author(s): 横田健一, 柴田洋孝, 伊藤裕
  • Total Pages: 166-168