Regulation of mitochondria by vascular hormones and the pathophysiological significance.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791063
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Endocrinology
• Research Institution: Keio University
• Principal Investigator: MIYASHITA Kazutoshi 慶應義塾大学, 医学部, 特任講師 (50378759)
• Research Collaborator: MITSUISHI Masanori 慶應義塾大学, 医学部, 大学院生 ; MURAKI Ayako 慶應義塾大学, 医学部, 助教 ; TAMAKI Masanori 慶應義塾大学, 医学部, 助教
• Project Period (FY): 2011 – 2012
• Keywords: 心血管ホルモン / ミトコンドリア / 酸素消費 / エネルギー代謝 / 生活習慣病 / 身体能力 / 骨格筋 / 抗加齢

Research Abstract

Recent papers reported that loss of physical performance is associated with increased risk of metabolic syndrome and shortening of life span. The present study demonstratedthat mitochondrial dysfunction is associated with deterioration in physical perform

Research Products

• [Journal Article] 1.Coenzyme Q10 reverses mitochondrial dysfunction in atorvastatin-treated mice and increases exercise endurance (2012)
  • Author(s): Muraki A, Miyashita K*, Mitsuishi M, Tamaki M, Tanaka K, Itoh H.
  • Journal Title: J Appl Physiol Pages: 479-486
  • Peer Reviewed
• [Presentation] High protein diet exacerbates decrease in muscle mitochondria and exercise endurance after 5/6 nephrectomy in mice (2012)
  • Author(s): Tamaki M, Miyashita K, Wakino S, Mitsuishi M, Tanaka K, Hayashi K, Itoh H.
  • Organizer: 45th Annual Meeting of American Society of Nephrology.
  • Place of Presentation: San Diego (United States of America)
  • Year and Date: 2012-11-02
• [Presentation] 骨格筋ミトコンドリア機能不全を基盤とした病態におけるグレリンの意義 (2012)
  • Author(s): 三石正憲,宮下和季,村木絢子,田蒔昌憲,田中久美子,伊藤裕
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-05-18
• [Presentation] The effect of ghrelin on the mitochondrial dysfunction in muscle and physical disability associated with aging. (2012)
  • Author(s): Mitsuishi M, Miyashita K, Muraki A, Tamaki M, Tanaka K, Itoh H.
  • Organizer: 15th International Congress of Endocrinology
  • Place of Presentation: Florence (Italy)
  • Year and Date: 2012-05-06
• [Presentation] Altered muscle mitochondrial amount and physical performance in CKD model mice (2012)
  • Author(s): Tamaki M, Miyashita K, Wakino S, Mitsuishi M, Tanaka K, Hayashi K, Itoh H.
  • Organizer: 15th International Congress of Endocrinology
  • Place of Presentation: Florence (Italy)
  • Year and Date: 2012-05-06
• [Presentation] 加齢に伴う身体能力の低下のグレリンによる改善 (2012)
  • Author(s): 三石正憲,宮下和季,村木絢子,田蒔昌憲,田中久美子,伊藤裕
  • Organizer: 第85回日本内分泌学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-04-21
• [Presentation] 骨格筋加齢機構の解明と加齢により低下する内分泌因子の補充による身体能力の改善の試み (2011)
  • Author(s): 三石正憲,宮下和季,村木絢子,田蒔昌憲,田中久美子,伊藤裕
  • Organizer: 第34回日本高血圧学会総会
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-10-22
• [Presentation] コエンザイムQ10は酸素利用を制御してアトロバスタチンによる運動耐容能低下を改善する (2011)
  • Author(s): 宮下和季,村木絢子,三石正憲,田蒔昌憲,伊藤裕
  • Organizer: 第11回日本抗加齢医学会総会
  • Place of Presentation: 京都
  • Year and Date: 2011-05-27
• [Presentation] 慢性腎臓病モデルマウスの骨格筋ミトコンドリアと身体能力 (2011)
  • Author(s): 田蒔昌憲,宮下和季,三石正憲,伊藤裕
  • Organizer: 第84回日本内分泌学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2011-04-23
• [Remarks]
  • URL: http://www.keio-emn.jp/donation/01.html