2012 Fiscal Year Final Research Report
Elucidation of role of the serotonin signal in the pancreatic beta-cell proliferation during pregnancy.
| Project/Area Number |
23791064
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 妊娠 / 膵 β 細胞 / 細胞増殖 / セロトニン |
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| Research Abstract |
This study was aimed for the examination that a serotonin signal through 5-HT1b receptor and SERT participated in for pancreatic beta-cell proliferationduring pregnancy . Actually, increased expression of the 5-HT1b receptor and stable expression of SERT were identified when examined expression of 5-HT1b receptor and SERT during pregnancy . Therefore administration the antagonist to a pregnant mouse, it was revealed that a ratio of cell proliferation decreased, and it was suggested that a signal through 5-HT1b and SERT participated in pancreatic beta-cell proliferation during pregnancy .
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