Role of histone acetyltransferase, Hbo1, in hematopoiesis

2012 Fiscal Year Final Research Report

• Project/Area Number: 23791071
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Chiba University
• Principal Investigator: MIYAGI Satoru 千葉大学, 大学院・医学研究院, 助教 (20400997)
• Project Period (FY): 2011 – 2012
• Keywords: T細胞分化 / 造血幹細胞 / クロマチン / 転写制御

Research Abstract

Recent progress has clearly demonstrated the significance of transcriptional regulation by histone acetyltransferase (HAT)s in the hematopoietic system. Our previous study showed that Hbol-Brdl HAT complex is the major H3K14 HAT required for transcriptional activation of erythroid developmental regulator genes and is dispensable for erythroid differentiation. In this study, we show that Hbol-Brdl HAT complex also has an important role in the induction of CD8 expression and thereby the T cell differentiation.

Research Products

• [Journal Article] Role of SOX17 in hematopoietic development from human embryonic stem cells (2013)
  • Author(s): Nakajima-Takagi, Y., Osawa, M., Oshima, M., Takagi, H., Miyagi, S., Endoh, M., Endo, T.A., Takayama, N., Eto, K., Toyoda, T., Koseki, H., Nakauchi, H. and Iwama, A
  • Journal Title: Blood Volume: 121 Pages: 447-458
  • DOI: doi:10,II82/blood-2012-05-431403.
  • Peer Reviewed
• [Journal Article] Bmil confers resistance to oxidative stress on hematopoietic stem cells (2012)
  • Author(s): Nakamura, S., Oshima, M., Yuan, J., Saraya, A., Miyagi, S., Konuma, T., Yamazaki, S., Osawa, M., Nakauchi, H., Koseki, H. and Iwama, A
  • Journal Title: PLoS ONE Volume: 7 Pages: e36209
  • DOI: doi:10.1371/journal.pone.0036209.
  • Peer Reviewed
• [Journal Article] 3-deazaneplanocin is a promising therapeutic agent for the eradication of tumor-initiating hepatocellular carcinoma cells (2012)
  • Author(s): Chiba, T., Suzuki, E., Negishi, M., Saraya, A., Miyagi, S., Konuma, T., Tanaka, S., Tada, M., Kanai, F., Imazeki, F., Iwama, A. and Yokosuka, O
  • Journal Title: Int I Cancer Volume: 130 Pages: 2557-2567
  • DOI: doi:10.1002/ijc.26264.
  • Peer Reviewed
• [Journal Article] Aldehyde dehydrogenase 1 is associated with recurrence-free survival but not stem cell-like properties in hepatocellular carcinoma (2012)
  • Author(s): Suzuki, E., Chiba, T., Zen, Y., Miyagi, S., Tada, M., Kanai, F., Imazeki, F., Miyazaki, M., Iwama, A. and Yokosuka, O
  • Journal Title: Hepatol Res Volume: 42 Pages: 1100-1111
  • DOI: doi:10.1111/i.1872-034X.
  • Peer Reviewed
• [Journal Article] Ezh2 augments leukemogenicity by reinforcing differentiation blockage in acute myeloid leukemia (2012)
  • Author(s): Tanaka, S., Miyagi, S., Sashida, G., Chiba, T., Yuan, J., Mochizuki-Kashio, M., Suzuki, Y., Sugano, S., Nakaseko, C., Yoko te, K., Koseki, H. and Iwama, A
  • Journal Title: Blood Volume: 120 Pages: 1107-1117
  • DOI: doi:10.1182/blood-2011-1-394932.
  • Peer Reviewed
• [Journal Article] Emx2 is a dose-dependent negative regulator of Sox2 telencephal ic enhancers (2012)
  • Author(s): Mariani, J., Favaro, R., Lancini, C., Vaccari, G., Ferri, AL., Bertolini, J., Tonoli, D., Latorre, E., Caccia, R., Ronchi, A., Ottolenghi, S., Miyagi, S., Okuda, A., Zappavigna, V. and Nicolis, SK
  • Journal Title: Nucleic Acids Res Volume: 40 Pages: 6461-6476
  • DOI: doi:10.1093/nar/gks295.
  • Peer Reviewed
• [Journal Article] Lethal myelofibrosis induced by Bml-deficient hematopoietic cells unveils a tumor suppressor function of the polycomb group genes (2012)
  • Author(s): Oguro, H., Yuan, J., Tanaka, S., Miyagi, S., Mochizuki-Kashio, M., Ichikawa, H., Yamazaki, S., Koseki, H., Nakauchi, H. and Iwama, A
  • Journal Title: I Exp Ned Volume: 209 Pages: 445-454
  • DOI: doi:10.1084/jem.20111709.
  • Peer Reviewed
• [Journal Article] Direct activation of STAT5 by ETV6-Lyn fusion protein promotes induction of myeloprol iferative neoplasm with myelof ibros is (2011)
  • Author(s): Takeda, Y., Nakaseko, C., Tanaka, H., Takeuchi, M., Yui, M., Saraya, A.,Miyagi, S., Wang, C., Tanaka, S., Ohwada, C., Sakaida, E., Yamaguchi, N., Yoko te, K., Hennighausen, L. and lwama A
  • Journal Title: Br J Haematol Volume: 153 Pages: 589-598
  • DOI: doi:10.1111/j.1365-2141.2011.08663.x.
  • Peer Reviewed
• [Journal Article] Forced expression of the histone demethylase Fbx110 maintains self-renewing hematopoietic stem cells (2011)
  • Author(s): Konuma, T., Nakamura, S., Miyagi, S., Negishi, M., Chiba, T., Oguro, H., Yuan, J., Mochizuki-Kashio, M., Ichikawa, H., Miyoshi, H., Vidal, M. and Iwama, A
  • Journal Title: Exp liesatol Volume: 39 Pages: 697-709
  • DOI: doi:10.1016/j.exphem.2011.03.008.
  • Peer Reviewed
• [Journal Article] The Hbol-Brdl/Brpf2 complex is responsible for global acetylationof H3K14 and required for fetal liver erythropoies is (2011)
  • Author(s): Mishima, Y., Miyagi, S., Saraya, A., Negishi, M., Endoh, M., Endo, TA., Toyoda, T., Shinga, J., Katsumoto, T., Chiba, T., Yamaguchi, N., Kitabayashi, I., Koseki, H. and Iwama, A
  • Journal Title: Blood Volume: 118 Pages: 2443-2453
  • DOI: doi:10.1182/blood-2011-01-331892.
  • Peer Reviewed
• [Journal Article] Dependency on the polycomb protein Ezh2 distinguishes fetal from adult hematopoietic stem cells (2011)
  • Author(s): Mochizuki-Kashio, M., Mishima, Y., Miyagi, S., Negishi, M., Saraya, A., Konuma, T., Shinga, J., Koseki, H. and Iwama, A
  • Journal Title: Blood Volume: 118 Pages: 6553-6561
  • DOI: doi:10.1182/blood-2011-03-340554.
  • Peer Reviewed