2012 Fiscal Year Final Research Report
Analysis of the function of KLF5 in blood cells and elucidation of its underlying molecular mechanism which leads to clinical application
| Project/Area Number |
23791072
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 血球細胞 / 巨核球 / 血小板 / 血管新生 / 転写因子 |
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| Research Abstract |
With a broad analysis of the function of KLF5 in blood cells, I found that KLF5 is critical especially to normal functions of platelets. Platelet lineage-specific Klf5-knockout mice showed impaired in vivo thrombus formation and angiogenesis activity, and I investigated the underlying molecular mechanisms. Our results can lead to future therapeutic interventions for various cardiovascular and cancer diseases
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