2012 Fiscal Year Final Research Report
Regulations of hematopoietic stem cell system by the control ofintracellular ATP
| Project/Area Number |
23791076
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hematology
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| Research Institution | Kanazawa University |
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Principal Investigator |
TADOKORO Yuko 金沢大学, がん進展制御研究所, 助教 (00447343)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 幹細胞 / 細胞内ATP |
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| Research Abstract |
Many tissue specific stem cells stay dormant. Therefore, the regulation of intracellular ATP is important for the control of the longevity or behaviors of stem cells. The LKB1-AMPK signaling functions as an intracellular energy sensor. To examine the role of LKB1 or AMPK in the regulatory system of hematopoietic stem cell, I analyzed LKB1- or AMPK-deficient hematopoietic stem cells. Our data demonstrated that LKB1 and AMPK contributed to the maintenance of hematopoietic stem cells.
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